Immunoadsorption for rheumatic diseases

Rheumatism is a very common disease in daily life. It can cause great harm to the patient's health and also affect their normal life and work, so it is particularly important to find a scientific and effective treatment method. The immunoadsorption therapy method has significant effects in the treatment of rheumatoid arthritis. Friends in need can learn more about the relevant knowledge before choosing whether to use this method.

1. Basic information of immunoadsorption

Immunoadsorption (IA) therapy is a blood purification technology developed in the past 15 years. It combines highly specific antigens, antibodies or substances with specific physical and chemical affinity (ligands) with adsorption materials (carriers) to form adsorbents (columns), which selectively or specifically remove pathogenic factors in the blood, thereby purifying the blood and alleviating the condition. Immunoadsorption therapy is different from general non-specific blood perfusion. Immunoadsorption therapy is a new technology developed on the basis of plasma exchange. Its advantage is that it is more selective in removing pathogenic factors in plasma, with a smaller range and amount of loss of useful components in plasma, while avoiding various adverse effects caused by plasma transfusion.

2. Immunoadsorption for the treatment of rheumatic diseases

If rheumatoid arthritis disease is active, immunoadsorption therapy can be considered. It is recommended to go to the rheumatology and immunology clinic first to complete relevant examinations to evaluate the current disease activity and whether immunoadsorption therapy is necessary.

The key part of immunoadsorption therapy is the adsorption column, which includes the carrier part, the ligand part and the connection method between the two. Immunoadsorption can be tried to treat rheumatic diseases. The core part that undergoes adsorption reaction with the adsorption object (pathogenic substance) is called the carrier, and the substance fixed on the carrier and having immunoadsorption activity is called the ligand. The two interact with each other through cross-linking or coupling. The adsorption activity of the ligand is essentially the selective or specific affinity between it and the adsorbed object (pathogenic substance), that is, the intermolecular interaction, including biological affinity (such as antigen-antibody reaction) and physicochemical affinity (such as hydrophobic interaction).

The basic operating procedure of immunoadsorption therapy is to draw the patient's blood out of the body, establish extracorporeal circulation and anticoagulate, let the blood flow through a plasma separator to separate the plasma, introduce the plasma into the immunoadsorbent to contact with the immunoadsorbent, remove pathogenic substances by selective adsorption, and then return the purified plasma to the patient to achieve the treatment purpose. Immunoadsorption can be tried to treat rheumatic diseases. Some immunoadsorption devices do not require plasma separation and can directly perform blood perfusion immunoadsorption therapy.