Amyloid nephropathy treatment

Amyloid nephropathy, also known as amyloid nephropathy, is a kidney disease mainly caused by the deposition of a large amount of amyloid fibers in the body. The symptoms of amyloid nephropathy are similar to those of nephrotic syndrome. Patients will develop renal failure in the late stage, and the harm caused can be imagined. Therefore, treatment has become the most important concern for patients. So, what is the treatment for amyloid nephropathy? Let’s take a look below.

Causes

Amyloid is an amorphous, glassy, ​​transparent substance that contains AL protein (amyloid protein), AA protein (amyloid protein A), prealbumin, peptide proteins, Bz microglobulin, etc. Macrophages are considered to be the main site for the formation and degradation of amyloid in the body. When the production of amyloid exceeds the ability of macrophages to metabolize protein, amyloid is deposited in tissues. Amyloidosis is divided into: 1. Primary (or idiopathic).

Treatment 1. Treatment of the underlying disease. 2. The efficacy of cytotoxic drugs in the treatment of amyloid nephropathy is still uncertain. Phenylalanine mustard (Melphalan) can significantly reduce proteinuria in the treatment of amyloidosis-nephropathy caused by multiple myeloma. 3. Colchicine Colchicine is recommended for the treatment of amyloidosis caused by familial Mediterranean fever, 1 to 1. 5mg/d can reduce the onset of amyloidosis and relieve symptoms. Hemodialysis is used for renal failure caused by amyloid nephropathy. Prognosis Compared with other glomerular diseases, the prognosis of this disease is poor, and heart failure, arrhythmia, sudden death and renal failure are the main causes of death.