Tiopronin Injection

Tiopronin injection is mainly used to treat acute and chronic hepatitis. It has a certain therapeutic effect on restoring and improving liver function. It is often used to treat drug-induced liver damage, fatty liver, or alcoholic liver. It also helps to reduce toxic and side effects during chemotherapy, and has obvious therapeutic effects on early senile cataracts. When taking medication, you need to be aware of allergic reactions and adverse reactions.

Indications

1. Used to improve liver function in various types of acute and chronic hepatitis. 2. Used for the treatment of fatty liver, alcoholic liver, drug-induced liver damage and detoxification of heavy metals. 3. It can reduce the toxic and side effects of radiotherapy and chemotherapy, and prevent peripheral leukopenia and the occurrence of secondary tumors caused by radiotherapy and chemotherapy. 4. It has a significant therapeutic effect on early senile cataracts and vitreous opacities.

Dosage

Intravenous drip, 0.2 g each time, once a day, for 4 weeks. Preparation method: Dissolve in 5%-10% glucose injection or 250-500ml of normal saline before use, and drip intravenously as usual.

Adverse Reactions

1. Allergic reactions Among the 1,560 adverse reaction case reports collected after the marketing of tiopronin injection, 115 cases of serious adverse reactions were reported, mainly 79 cases of anaphylactic shock (1 death). Other adverse reactions include rash, itching, nausea, vomiting, fever, chills, dizziness, palpitations, chest tightness, parotid gland enlargement, laryngeal edema, difficulty breathing, allergic reactions, etc. 2. This drug may cause all the adverse reactions of penicillamine, but the frequency of its adverse reactions is lower than that of penicillamine. 3. Agranulocytosis is rare in the blood system, and thrombocytopenia is occasionally seen. If the peripheral white blood cell count drops below 3.5×106 per milliliter, or the platelet count drops below 10×106 per milliliter, it is recommended to stop the medication. 4. Proteinuria may occur in the urinary system, with an incidence of about 10%, and it usually recovers quickly after stopping the medication. There are also case reports that this drug can cause urine discoloration. 5. The digestive system may experience loss of taste, abnormal taste, nausea, vomiting, abdominal pain, diarrhea, loss of appetite, bloating, oral ulcers, etc. There are also reports of cholestasis and increased liver function test indicators (such as alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase, etc.). If abnormalities occur, this product should be discontinued or appropriate treatment should be initiated. 6. Skin reaction is the most common adverse reaction of this drug, with an incidence of about 10% to 32%. It manifests as rash, itching, redness, urticaria, skin wrinkles, pemphigus, yellowing of the skin and eyes, etc. Skin wrinkles usually occur only after long-term treatment. 7. Respiratory system: This drug has been reported to cause pneumonia, pulmonary hemorrhage and bronchospasm. There are also case reports of dyspnea or respiratory distress, as well as bronchiolitis obliterans. 8. Musculoskeletal: There are case reports that the use of this drug can cause muscle weakness. 9. Long-term and large-scale use may lead to rare proteinuria or nephrotic syndrome. 10. Others: In case of rare insulin autoimmune syndrome, the drug should be discontinued if fatigue and limb numbness occur.