Treatment of proteinuria

Proteinuria is a common kidney disease, mainly caused by the detection of a large amount of protein in the urine. That is, a lot of protein in the body is excreted, which is very harmful to the body. It will cause kidney diseases and even produce glomerular proteinuria and some other proteinuria. The main symptom of kidney disease is urine protein, which produces some chronic kidney disease and acute kidney disease. Below we will briefly introduce the treatment of proteinuria.

Proteinuria is mainly a kidney disease, which is mainly divided into selective proteinuria and non-selective proteinuria. Selective proteinuria mainly excretes less protein from the body, while non-selective proteinuria mainly excretes large and small molecules of protein. The simultaneous appearance of these proteins indicates that the situation is already very serious.

Proteinuria is a typical symptom of kidney disease, but the amount of urine protein leakage cannot reflect the severity of the kidney disease. In patients with mild chronic kidney disease, less urine protein leakage does not necessarily mean that the kidney pathological damage is mild; large amounts of proteinuria do not mean that the kidney pathological damage is severe. For example, in minimal change nephritis and mild mesangial proliferative nephritis, kidney lesions are mild, but the daily urine protein amount can reach several grams or even more than ten grams.

Generally speaking, proteinuria is divided into selective proteinuria and non-selective proteinuria. Selective proteinuria refers to the fact that protein electrophoresis is dominated by proteins with smaller molecular weight, such as albumin, α1 globulin, transferrin and γ globulin. Proteins with larger molecular weight, such as α2 globulin, fibrinogen, and β-lipoprotein, are present in lower amounts.

Patients with minimal change nephropathy, mild mesangial proliferative nephritis, some membranous nephropathy, early-stage membranous proliferative nephritis, and focal segmental sclerosing nephritis often present selective proteinuria, indicating that the damage to the glomerular filtration membrane is relatively mild.

Non-selective proteinuria refers to the simultaneous appearance of large and small molecular proteins in protein electrophoresis, indicating that the damage to the glomerular filtration membrane is relatively serious.

Nephrology experts analyzed that the amount of protein loss is not proportional to the severity of the disease. Patients with mild glomerular lesions may not necessarily have less urine protein. For example, in patients with minimal change nephritis and mild mesangial proliferative nephritis, the kidney lesions are mild, but the daily urine protein amount can reach several grams or even more than ten grams.

In contrast, some cases of focal segmental sclerosing nephritis and crescentic nephritis have severe pathological damage, but the daily urine protein level may be only a few grams. Therefore, the effectiveness of treatment depends mainly on the type of kidney pathology, the extent of damage and kidney function.

In addition, it also depends on whether the patient can cooperate with the doctor, whether he pays attention to preventing the occurrence of recurrence inducements (such as colds, fatigue, diarrhea, etc.), whether he can persist in treatment, and whether he avoids the use of nephrotoxic drugs.

The above are the medication and treatment methods for proteinuria. During the recovery period, you must consult the medical advice given by the expert. If the patient finds protein in the urine, he or she should also undergo corresponding examinations. In daily life, you should pay attention to good diet and health care and don’t panic too much. Timely control of some diet is also very important for the recovery of proteinuria. If you find proteinuria, you should seek medical treatment promptly and don't rush to seek medical treatment.