I believe everyone has heard of and seen birthmarks, but many people do not understand the causes of birthmarks. Lack of trace elements or melanin precipitation may induce birthmarks, so attention should be paid to nutritional supplements during pregnancy. Deficiency of trace elements: Congenital birthmarks are caused by severe deficiency of trace elements such as zinc, copper, calcium, magnesium, and phenylalanine and tyrosine in human serum. Frequent irritation of the affected area is also one of the important factors in the occurrence and development of birthmarks. Therefore, women should also pay attention to their diet during pregnancy. Melanin deposition Melanin is produced by melanocytes and is the main factor causing skin color changes. The production of eumelanin depends on the supply of tyrosine and oxygen, the activity of tyrosinase and the number of melanosomes produced, thus inducing birthmarks. Pathogenesis Histopathological examination showed melanocytes in the dermis, especially in the lower half, which were filled with melanin granules. Their dendrites were significantly elongated and thinned, often in a wavy shape, roughly parallel to the skin surface, and widely scattered between the collagen fiber bundles. The melanin granules they contained showed a positive DOPA reaction, indicating that they were not melanophages in the dermis. Under an electron microscope, these melanocytes contained countless completely melanized melanosomes. |
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