Dosage and administration of atropine sulfate injection

Atropine sulfate injection is also a relatively common drug. It mainly has a good therapeutic effect on visceral colic, such as gastrointestinal colic. It also has a good relieving effect on bladder irritation reactions. It is also an anti-shock drug and a common drug for rescuing organophosphate poisoning. It is used by intramuscular injection or intravenous injection. Let us learn about this aspect.

Dosage

1. The usual adult dose for subcutaneous, intramuscular or intravenous injection is 0.3-0.5 mg each time, 0.5-3 mg per day; the maximum dose is 2 mg once. Subcutaneous injection for children: 0.01-0.02 mg/kg each time, 2-3 times a day. Intravenous injection: For the treatment of Asperger's syndrome, 0.03-0.05 mg/kg each time. Repeat once every 15 minutes if necessary until the face flushes, circulation improves, and blood pressure rises. Extend the interval time until the blood pressure stabilizes. 2. For antiarrhythmics, the intravenous dose for adults is 0.5-1 mg, once every 1-2 hours as needed, with a maximum dose of 2 mg. 3. Detoxification (1) For the treatment of Adams-Stokes syndrome caused by antimony agents, inject 1-2 mg intravenously, and then inject 1 mg 15-30 minutes later. If the patient does not have an attack, inject 1 mg subcutaneously or intramuscularly every 3-4 hours as needed. (2) For organophosphorus poisoning, 1 to 2 mg is given by intramuscular or intravenous injection (the dose can be increased by 5 to 10 times in severe organophosphorus poisoning), and repeated every 10 to 20 minutes until the cyanosis disappears. The medication is continued until the condition stabilizes, and then a maintenance dose is used, which sometimes takes 2 to 3 days. 4. Anti-shock and improve circulation: For adults, the general dosage is 0.02-0.05 mg/kg body weight, diluted with 50% glucose injection and injected intravenously or diluted with glucose water and dripped intravenously. 5. Pre-anesthetic medication: Adults should be injected intramuscularly 0.5 mg 0.5 to 1 hour before surgery. The subcutaneous injection dose for children is: 0.1 mg for those weighing less than 3 kg, 0.2 mg for 7 to 9 kg, 0.3 mg for 12 to 16 kg, 0.4 mg for 20 to 27 kg, and 0.5 mg for those weighing more than 32 kg.

Indications

1. Various visceral colic, such as gastrointestinal colic and bladder irritation symptoms. 1. It has poor efficacy in treating biliary colic and renal colic; 2. It is used before general anesthesia for severe night sweats and drooling; 3. It is used for slow arrhythmias such as sinoatrial block and atrioventricular block caused by excessive vagal nerve excitement, and can also be used for ventricular ectopic nodes secondary to sinus node dysfunction; 4. It is used to resist shock; 5. It is used to rescue organophosphate poisoning.

Adverse Reactions

The adverse reactions caused by different doses are as follows: 0.5 mg, slight slowing of heart rate, slight dry mouth and little sweating; 1 mg, dry mouth, accelerated heart rate, slightly dilated pupils; 2 mg, palpitations, significant dry mouth, dilated pupils, and sometimes blurred vision; 5 mg, the above symptoms worsen, and there are slurred speech, irritability, dry and hot skin, difficulty urinating, and reduced intestinal motility; above 10 mg, the above symptoms are more severe, the pulse is rapid and weak, the central nervous system is seriously excited, the breathing becomes faster and deeper, and delirium, hallucinations, convulsions, etc. appear; in severe poisoning, the central nervous system excitement may turn into inhibition, resulting in coma and respiratory paralysis. The minimum lethal dose for adults is approximately 80~130 mg, and for children it is 10 mg. Use with caution in patients with fever, rapid pulse, diarrhea and in the elderly.