What are the symptoms of moyamoya disease patients?

In modern life, people's health level has declined rapidly, which has brought very destructive effects to people's bodies. In particular, some diseases that were relatively rare in the past have become more and more common, causing people to suffer great pain and torture. For example, moyamoya disease is a very harmful disease that causes great obstacles to the patient's life. Let's take a look at the symptoms of moyamoya disease patients.

Some scholars have found that mothers and children or siblings in some families may have similar diseases, which is considered to be related to congenital factors. However, based on clinical, pathological, immunological and laboratory studies, most scholars believe that this is a group of acquired occlusive cerebrovascular diseases that may be related to allergic cerebrovascular inflammation. The cause of moyamoya disease is still not very clear. The incidence rate among siblings is 42 times higher than that of ordinary people, and the incidence rate among children of patients is 37 times higher than that of normal people. Recently, it has been found that the occurrence of moyamoya disease is related to genetic abnormalities of chromosome 3 3p24.2-26; chromosome 6 D6s441 and chromosome 17. Therefore, some scholars believe that the occurrence of moyamoya disease may be related to genetics. In addition, many people are concerned about whether moyamoya disease is hereditary. From the current medical situation, there is no direct evidence to prove that moyamoya disease is hereditary - although there are data showing that in the case of inheritance, the incidence of moyamoya disease is 37 times the normal incidence.

Symptoms and Signs/Moyamoya disease Moyamoya disease is more common in children and adolescents, and often presents as a stroke, which can manifest as cerebral thrombosis, cerebral hemorrhage, and subarachnoid hemorrhage. Patients may experience varying degrees of hemiplegia, or successive paralysis of the left and right sides, which may be accompanied by aphasia, coughing when drinking water, dysphagia, mental retardation, dementia, epileptic seizures, headaches, and transient ischemic attacks.

Infarction or hemorrhagic changes can usually be seen on head CT scans. The bleeding may be lobar hemorrhage, basal ganglia hemorrhage or subarachnoid hemorrhage, and cerebral hemorrhage caused by hypertension is mostly located in the basal ganglia area. Infarct foci and/or brain atrophy may also be found in patients with cerebral hemorrhage. Cerebral angiography can reveal that the origin of the internal carotid artery and the origin of the anterior and middle cerebral arteries are narrowed or not visible, and a large number of small blood vessels can be seen in the basal ganglia area, like smoke exhaled by cigarettes. In addition, compensatory branches of collateral circulation can be seen in the brain. As the disease progresses, the number of compensatory anastomotic branches gradually decreases or shrinks.

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