Treatment of low glomerular filtration rate

As we all know, one of the five internal organs of the human body is the kidney, which is mainly responsible for removing harmful substances from the human blood and plays an important role in the human body. The transmission of harmful substances in the kidneys is mainly carried out by the glomerulus, which plays a filtering role. Abnormal glomerular filtration rate will cause many complications and harm to the human body. Therefore, glomerular filtration rate is an effective indicator for detecting kidney problems in clinical medicine. The main symptoms of lost glomerular filtration rate are: decreased urine volume, anuria, etc. This article will briefly introduce related issues.

A low glomerular filtration rate refers to the amount of ultrafiltrate produced by both kidneys per unit time (per minute), which is called the glomerular filtration rate. It is one of the important indicators to measure renal function.

Decreased glomerular filtration rate can be seen in

(1) Various primary and secondary kidney diseases that affect glomerular filtration function.

(2) As people age, the glomerular filtration rate gradually decreases. After the age of 40, the glomerular filtration rate decreases by 1.15 ml/min each year.

Normal reference value

For men it is (125 ± 15) ml/min; for women it is about 10% lower.

Low glomerular filtration rate

A decrease in glomerular filtration rate means that it is lower than the normal standard. The amount of filtrate generated by the two kidneys per unit time is called the glomerular filtration rate (GFR), which is about 125ml/min for a normal adult. The ratio of glomerular filtration rate to renal plasma flow is called filtration fraction. The renal plasma flow is about 660 ml per minute, so the filtration fraction is 125/660×100%≈19%. This result indicates that about 1/5 of the plasma flowing through the kidney is filtered into the cystic cavity by the glomerulus to form primary urine. Glomerular filtration rate and filtration fraction are measures of kidney function. A significant decrease in glomerular capillary blood pressure, renal vasoconstriction, changes in filtration membrane permeability and filtration area can all lead to a decrease in glomerular filtration rate.

How to treat low glomerular filtration rate

Such as lowering blood pressure, controlling infection, administering hormones and immunosuppressants, limiting protein and phosphorus intake, and prohibiting nephrotoxic drugs. Since the antihypertensive drugs used in conventional treatment only work to lower blood pressure, antibiotics mainly eliminate lesion infections, and the functions of hormones and immunosuppressive drugs are only to inhibit certain types of immune factors and certain immune activity links in the immune response, therefore, although the condition can be alleviated and relieved during treatment, the continued development of kidney disease cannot be avoided because the immune damage cannot be eliminated and the kidney's resistance to damage and repair function cannot be enhanced. This is also the main reason why chronic nephritis is difficult to cure.