Ginsenoside RG3 efficacy

Ginsenoside Rg3 is a rare ginsenoside currently widely used in auxiliary treatment of cancer. However, many people still do not understand the role and function of ginsenoside Rg3. Some people even doubt whether ginsenoside Rg3 can really prevent cancer? What are the functions and effects of ginsenoside Rg3? In 2018, a paper review systematically summarized the anti-cancer effects of ginsenoside Rg3. The authors of the thesis analyzed a large number of recent studies on the anti-tumor effects of ginsenoside Rg3 and found that ginsenoside Rg3 has five major anti-cancer effects.

1. Induce tumor cell necrosis

Cell necrosis refers to the independent and orderly death of somatic cells controlled by genetic genes in order to maintain the stability of the body's extracellular fluid. Studies have shown that ginsenoside Rg3 can increase the expression of necrosis factors such as Bax and Caspase, thereby inducing apoptosis of tumor cells. Current research has found that high concentrations and high dosages of ginsenoside Rg3 can induce apoptosis of various tumor cells such as lung adenocarcinoma, colon cancer, breast cancer, and gastric cancer, and fully exert its anti-cancer effect.

2. Inhibit tumor cell invasion and migration

The invasion and migration of tumor cells are the basis for the gradual spread of cancer and the occurrence of near and far migration. Ginsenoside Rg3 can significantly inhibit the erosion and migration of tumor cells. Studies have found that ginsenoside Rg3 can reduce the permeability of bladder cancer cells, thereby inhibiting their migration. Other studies have shown that high concentrations of ginsenoside Rg3 significantly reduce the ability of colorectal cancer cells to penetrate the cytoplasm, thereby inhibiting the metastatic ability of colorectal cancer cells. Some studies have also found that medium and high concentrations of ginsenoside Rg3 can inhibit breast cancer lung migration.

3. Cooperate with radiotherapy and chemotherapy to suppress drug resistance, reduce toxicity, improve quality and increase efficacy

Chemotherapy and radiotherapy are still the main methods of cancer treatment at present, but the multidrug resistance of tumor cells can lead to the failure of chemotherapy and radiotherapy. Studies have shown that ginsenoside Rg3 can inhibit the multidrug resistance of tumor cells, increase the sensitivity of tumors to chemotherapy drugs, thereby improving the efficacy of radiotherapy and chemotherapy, and alleviate the side effects of chemotherapy drugs. Scientific research shows that ginsenoside Rg3 can inhibit the resistance of colorectal cancer cells to the chemotherapy drug fluorouracil in various ways, thereby improving the effect of chemotherapy. Ginsenoside

Rg3 can work synergistically with radiotherapy and chemotherapy to reduce toxicity, improve quality and increase efficacy, greatly improving the efficacy of radiotherapy and chemotherapy in patients with non-small cell lung cancer.

Studies have also found that ginsenoside Rg3 combined with chemotherapy and radiotherapy can prolong the survival of patients with advanced non-small cell lung cancer, improve the patient's symptoms, and reduce the side effects of chemotherapy and radiotherapy, such as low white blood cell count and platelet count.

4. Inhibit neonatal angiogenesis

The growth and migration of tumors must depend on the formation of blood vessels. Tumor angiogenesis is an extremely complex process. Inhibiting the formation of tumor angiogenesis plays an important role in inhibiting the proliferation and migration of tumor cells and the expansion of tumors. Studies have already found that ginsenoside Rg3 can resist tumor angiogenesis and inhibit the angiogenesis of pancreatic cancer, breast cancer, and colorectal cancer.

5. Enhance the body's immune ability

Immunity is the body's key ability to identify and deal with tumor cells, bacteria, and viral infections. Tumors can destroy the body's immune function, causing the patient to have low immunity. Studies have shown that ginsenoside Rg3 can enhance the specificity of immune cells, promote the conversion of immune factors, thereby enhancing the body's immune function and improving anti-cancer ability.

A variety of ginsenosides work together to create a stronger effect

In cancer treatment, the synergistic use of various new anti-cancer drugs has become a new trend. The same is true for ginsenosides. Ginsenoside Rg3 has the above 5 anti-cancer effects, and other ginsenosides, such as Rh2, Rg5, Rk2, Rh3, aPPD, etc., also have rich anti-cancer effects. Studies have found that a variety of ginsenosides combined together have a synergistic effect with each other, and the resulting anti-cancer effect is stronger than that of a single ginsenoside. Therefore, the combination of various ginsenosides to produce multi-component ginsenoside products can provide greater help to patients.