Mesenchymal malignancies

There are many cancer patients in our lives, but cancer patients generally only have tumors in one part of the body, that is, tumors caused by one lesion. Very few patients have tumors in two parts of the body. If these two diseases occur at the same time, as a mesenchymal malignant tumor, this tumor is quite troublesome to treat. So what should you do if you have a mesenchymal malignant tumor?

Malignant mesenchymoma refers to a malignant tumor composed of two or more mesenchymal components and is extremely rare. It can occur in the limbs, retroperitoneum, bones, gastrointestinal tract, pleura, lungs, etc. This case occurred in the lower femur and was composed of malignant mesenchymal components such as rhabdomyosarcoma, well-differentiated chondrosarcoma and synovial sarcoma, and the tumor severely destroyed the bone tissue. This disease is difficult to distinguish from osteosarcoma clinically and on X-rays. Morphology is mainly used to differentiate it from benign mesenchymal tumors: although the latter also has a variety of mesenchymal components, the various cells are well differentiated, without atypia, nuclear division phase, and no evidence of malignant morphology.

diagnosis

Macroscopic examination: The specimen was an irregular gray-white and gray-red mass with small pieces of cartilage tissue, totaling 4×3×2.5cm. The cut surface was gray-white and brittle.

Pathological microscopic observation: Most of the sections showed pleomorphic rhabdomyosarcoma, synovial sarcoma and differentiated chondrosarcoma. The rhabdomyosarcoma cells in the tumor are large in size, with abundant eosinophilic cytoplasm, eccentric nuclei, round or short spindle-shaped, darkly stained nuclei, multinucleated tumor giant cells, and nuclear divisions can be seen. Myoglobin (+); synovial sarcoma shows irregular fissures with epithelial lining and mild papillary processes