What is Central Nervous System Leukemia

Everyone may not know much about central nervous system leukemia. In fact, it is a common complication of leukemia. It can cause a lot of health damage and life impact for patients. Therefore, you must actively receive treatment for this disease, especially in life. If you do not understand the common sense in this area, you should consult a doctor as soon as possible.

Because not everyone can understand these disease problems, so sometimes we can't blindly find ways to treat them ourselves, because if it is incorrect, not only will it have no therapeutic effect, it may also cause harm to your health, so I hope that patients can pay attention to it.

Central nervous system leukemia (CNS-L) is a clinical symptom and sign caused by the extramedullary infiltration of leukemia cells into the arachnoid membrane or the nerve tissue adjacent to the arachnoid membrane. It is a common complication of leukemia and has an important impact on prognosis. CNS-L is mainly seen in acute leukemia (AL), and rarely occurs in patients with chronic leukemia.

Chronic lymphocytic leukemia is even more rare, called CNS-L. AL is more common in acute lymphoblastic leukemia (ALL) and M4 and M5 types in acute myeloid leukemia (AML). Most patients with hyperleukocytosis (white blood cell count>100×109/L) will develop CNS-L during the course of the disease, and the incidence of T-cell ALL is also very high. The incidence of childhood ALL complicated by CNS-L is much higher than that of adult ALL.

Symptoms and signs

In about half of the patients, CNS-L develops within 1 to 5 months after the diagnosis of AL, 81.5% occur before complete remission or during relapse, and only 18.3% occur during complete remission. In a small number of patients, CNS-L is the first manifestation of leukemia and is easily misdiagnosed as other central nervous system diseases. Among the 118 cases of CNS-L in the Peking Union Medical College Hospital mentioned above, 11.5% of the cases had CNS-L as the initial clinical manifestation of leukemia.

The above is an introduction to central nervous system leukemia. I hope that after reading this introduction, you can have a more comprehensive understanding of this disease. When you find yourself in a similar situation in life, you must pay attention and receive professional examinations as soon as possible to avoid causing greater harm to yourself.