What are the "signals" of ankylosing spondylitis?

Ankylosing spondylitis is a chronic progressive systemic disease that mainly affects the spine, primarily the sacroiliac joints, hip joints, intervertebral joints and costovertebral joints. So what are the causes of ankylosing spondylitis?

Symptoms of ankylosing spondylitis

1. Anemia

Clinically, patients with ankylosing spondylitis will have symptoms of anemia, and the number of white blood cells and platelets in their bodies will be normal, but the serum iron and total iron binding capacity in the blood cells are very abnormal. It is difficult to detect anemia in many patients, so it is easily ignored by patients clinically. Therefore, experts recommend that patients should do more examinations during the onset of the disease so that abnormal symptoms can be discovered in time.

2. Fever symptoms

Clinically, ankylosing spondylitis is found to have symptoms of fever, and the body temperature is between 37 and 38 degrees Celsius, and it is discovered at night and returns to normal after the disease. If there is such a history in a family and the patient has symptoms of unexplained fever, experts here recommend that enough attention should be paid and sufficient vigilance should be aroused.

3. Chronic inflammatory lower back pain

Clinically, patients with ankylosing spondylitis experience chronic back pain, which is the earliest symptom of the patient. It is relatively hidden in clinical practice and often lasts for more than 3 months. The pain will worsen after the patient rests. What symptoms of ankylosing spondylitis are easily ignored? The pain will be relieved after exercise, and clinically there will be symptoms of joint stiffness, hip or joint pain, which are often ignored by patients in clinical practice.

Genetic factors are one of the causes of ankylosing spondylitis

Ankylosing spondylitis has a familial genetic tendency, and genetic factors play a decisive role in the onset of this disease. In 1973, a study found that the disease is related to human leukocyte antigen B27 (HLA-B27 for short), and about 90% of ankylosing spondylitis patients are HLA-B27 positive. It is now highly suspected that HLA-B27 is the genetic susceptibility gene for this disease.

The second cause of ankylosing spondylitis is infection

Klebsiella pneumoniae infection as a trigger for ankylosing spondylitis

Some studies in recent years have shown that infection with Klebsiella pneumoniae is a triggering factor for ankylosing spondylitis. The positive rate of Klebsiella detected in the feces of patients with ankylosing spondylitis is significantly higher than that of normal people or other arthritis patients, and is significantly correlated with the active stage of the disease.

The third cause of ankylosing spondylitis: endocrine factors

There are significant differences in the age and gender of ankylosing spondylitis, which is more common in young and middle-aged men.

There are significant differences in the age and gender of onset of ankylosing spondylitis. It is more common in young and middle-aged males, with an onset age of 10-40 years old, a peak age of 20-30 years old, and the incidence rate decreases significantly after the age of 40. The incidence rate in women is significantly lower than that in men, with the male-to-female ratio being approximately 7-10:1. The condition in female patients is milder and rarely leads to ankylosing of the spine. This shows that this disease is related to endocrine.