What is myelohypoplastic disease?

Low bone marrow proliferation is because the internal environment of the bone marrow is destroyed, which leads to disorders in the hematopoietic function of the bone marrow and causes some blood-related diseases in patients. Under normal circumstances, the bone marrow is active. If the bone marrow is particularly active and overactive, it will cause leukemia. When the bone marrow proliferation is low, it is easy to suffer from hematopoietic dysfunction.

What is myelohypoplastic disease?

1. Myelohypoplasia is a blood disease and a type of myelodysplasia syndrome, that is, a disorder of red blood cell, white blood cell and platelet proliferation, with anemia, bleeding and infection as the main characteristics! It is recommended to go to the hospital for a detailed examination to find out the cause. Generally, better results can be achieved through treatment!

2. Decreased bone marrow proliferation is mainly due to the destruction of the internal environment of the bone marrow, which leads to a decrease in the production of tri-lineage cells in the bone marrow, resulting in symptoms such as anemia, bleeding, and infection. Normal bone marrow proliferation is active. If the bone marrow is overactive it is leukemia. Decreased bone marrow proliferation is common in aplastic anemia.

The significance of bone marrow hyperplasia is divided into 5 levels according to the degree of hyperplasia:

Grade I: Extremely active proliferation, mainly seen in acute and chronic leukemia, and occasionally in certain proliferative anemias.

Grade II: The proliferation is obviously active, which is common in various proliferative anemias, such as iron deficiency anemia, megaloblastic anemia, hemolytic anemia, etc., or certain leukemias.

Grade III: Active proliferation, seen in the bone marrow of normal people, some anemias with poor compensatory proliferation, and also seen in cases of partial blood dilution during bone marrow sampling. Grade IV: Decreased proliferation, commonly seen in aplastic anemia and partial dilution of the bone marrow by blood.

Grade V: Extremely reduced proliferation, seen in typical aplastic anemia.

A significant increase in the ratio of granulocytes to immature erythrocytes (granulocyte/erythrocyte ratio) is seen in:

⑴ Increase in granulocytes, such as acute or chronic myeloid leukemia, infection, especially suppurative infection, leukemoid reaction, etc.

⑵ Inhibition of erythroid cell production, such as pure erythroplasty.

Normal proportions are seen in:

⑴ Normal human bone marrow;

⑵ The two lineages of cells increase or decrease simultaneously or proportionally, such as in aplastic anemia, myelofibrosis, intramedullary tumor, bone marrow metastatic cancer, etc.

The reduction in proportion is seen in:

⑴ Granulocytopenia, such as granulocytopenia or deficiency, chemotherapy, radiation sickness, etc.;

⑵ Increase in erythroid cells, such as hemolytic anemia, iron deficiency anemia, megaloblastic anemia, polycythemia vera, hypersplenism, etc.