How long does it take to recover from rhabdomyolysis?

Rhabdomyolysis is a relatively serious disease. It affects the skeletal muscle cell membrane, causing damage to the skeletal muscle, and ultimately causing acute renal failure and metabolic disorders in patients. The causes of rhabdomyolysis are relatively complex, including genetic factors and poor diet. This disease should be treated in a timely manner, and the first thing to do is to ensure normal kidney function.

Etiology : The etiology of striated muscle is very complex. Foreign studies have pointed out that there are more than 190 acquired causes and more than 40 genetic causes. Common causes include excessive exercise, muscle crush injury, ischemia, metabolic disorders (hypokalemia, hypothyroidism, diabetic ketoacidosis), extreme body temperature (high fever, low fever), drugs, poisons, autoimmunity, infection, etc.

Common genetic factors include creatine phosphodiesterase deficiency, botulinum toxin acyltransferase II deficiency and other causes. The main pathophysiological mechanisms include ischemic damage and ATP depletion, impaired sarcoplasmic reticulum calcium regulation, hypokalemia, and tissue oxidative stress. Among them, the direct damage of myoglobin to the kidneys is the most direct cause of acute renal failure. When acute renal failure caused by rhabdomyolysis occurs, the pathology is acute tubular necrosis; the mechanism of occurrence is: ① tubular obstruction; ② tubular oxidative damage; ③ renal ischemia (including vasoconstriction and hypovolemia).

The main purpose of treatment : to protect renal function. 1. Stabilize the patient's vital signs and pay attention to the monitoring of intake and output; 2. Remove the inducement of rhabdomyolysis; avoid risk factors that aggravate rhabdomyolysis. 3. Prevention of acute tubular necrosis: ① Volume resuscitation; ② Alkalinization of urine; ③ Use of antioxidants to protect tubular cells; ④ Hemodialysis or hemofiltration: If acute renal failure has occurred, renal replacement therapy may be required until renal function recovers.