How to avoid renal failure due to drug poisoning?

Many people take medicines without the arrangement and guidance of a doctor, which may cause drug poisoning. In particular, mixing various medicines together is most likely to cause drug poisoning, which may lead to unnecessary trouble. Therefore, you must pay attention to it in normal times and go to the hospital as soon as possible after drug poisoning to prevent complications.

2. Strengthen poison management: Strictly abide by the poison protection and management system, strengthen the storage of poisons, and prevent the leakage of poisons.

3. Prevent accidental ingestion of poisons or overdose: Containers of drugs and chemicals must be labeled separately, and hospitals must have a strict drug checking system to avoid accidental ingestion or overdose.

Pathological etiology Factors affecting drug poisoning It is generally believed that the occurrence of drug poisoning is mainly related to the following factors

1. Medication management

With the development of the chemical pharmaceutical industry, if management cannot keep up, the occurrence of drug poisoning will increase.

2. Regional diseases are also an important factor

For example, in areas of China where schistosomiasis is endemic, hexachloroparaxylene is widely used and the incidence of toxic neuropathy and neurosis is also high.

3. Genetic factors

It is an important cause of toxicity of some drugs. Glucose 6-phosphate dehydrogenase (G6PD) deficiency accounts for an important part of the hemolytic anemia that occurs when quinine antimalarial drugs are used. People with G6PD deficiency are widely distributed in China, with higher positive rates in southwestern and coastal provinces and cities. About 23% of chronic acetylating patients who use isoflurane for a long time suffer from multiple peripheral neuritis. Among European Caucasians, 60% are slow acetylation patients, while in China, about 20% are. For patients with pseudocholesterol deficiency, taking the same dose of the muscle relaxant succinylcholine will prolong the interval between exhalation and inhalation, and in severe cases, cause suffocation and death. The metabolism of alcohol in the body mainly relies on acetaldehyde dehydrogenation. People who lack acetaldehyde dehydrogenation are prone to alcohol poisoning. Europeans have almost no deficiency, but more Asians are deficient in acetaldehyde dehydrogenase than Europeans, with the figure among Chinese being about 35%.

4. Differences in gender and age

Susceptibility to drug toxicity varies widely. Chloramphenicol can cause aplastic anemia, which is three times more common in women than in men. More care should be taken when using medication in children, because children's drug metabolism is not fully developed and they are highly sensitive to drug toxicity. For example, chloramphenicol can cause gray baby syndrome, and the child may die within hours of the onset of symptoms. Children's kidneys excrete streptomycin slowly, and long-term use can cause deafness. The heart, liver and kidney functions of the elderly are declining, making them more susceptible to allergic reactions or poisoning. For the same dose of digoxin, the plasma half-life is prolonged and the incidence of digitalis poisoning is high. The renal excretion function of the elderly is reduced, and the plasma concentration of penicillin after intramuscular injection is 13 times higher than that of young people. The dosage of barbiturate hypnotics should be adjusted in the elderly because their liver's drug metabolism activity decreases. Elderly people use many types of medications for long periods of time, and the incidence of drug toxicity and side effects is also higher.

Complications of drug poisoning, if not treated promptly, can cause complications such as heart failure, respiratory failure, and in severe cases, death.