Early symptoms of blood diseases in children

Blood disease in children is a relatively common disease with a relatively high incidence rate. The most common one is leukemia. The main causes of leukemia are chemical factors, immune factors, genetic factors, etc. When a child develops blood disease in the early stages, the most common one is anemia, which can easily cause the patient to have a fever, cause bleeding symptoms in the child, and often cause pain in the bones and joints.

Early symptoms of blood diseases in children

1. Anemia: It is the most common early symptom and may progressively worsen. The child's complexion and skin mucous membranes are pale, he is weak and has a poor appetite.

2. Fever: This is the most common first symptom. Due to the lack of normal white blood cells, especially mature granulocytes, the body's normal defense function is impaired, so infection can cause fever.

3. Bleeding: More than half of the children have bleeding to varying degrees, mainly manifested as bleeding in the nasal mucosa, oral cavity, gums and skin. In severe cases, internal organs and intracranial bleeding occur, which can often result in the death of the child.

4. Bone and joint pain and bone lesions: common in children with acute leukemia and may be the first symptom.

What are the causes of blood diseases in children?

Aplastic anemia

Most commonly used anti-cancer drugs have the side effect of inhibiting bone marrow hematopoiesis, and it is dose-related, such as doxorubicin, cytarabine, cyclophosphamide, phenylalanine mustard, etc. Some drugs are not harmful to most people at normal doses. However, it can cause aplastic anemia in some people (it has little to do with the dosage), such as chloramphenicol and sulfonamide drugs.

Thrombocytopenia and hemostatic dysfunction

Some drugs can cause bone marrow hypoplasia, direct platelet destruction, or immune thrombocytopenia. Commonly used drugs include rifampicin, antipyretic analgesics, sulfonamides, antidiabetic drugs, sedatives, hydrochlorothiazide, digoxin, methyldopa, ethosuximide, metronidazole, cefotaxime, erythromycin, etc. Some drugs can cause platelet dysfunction and affect hemostasis function. Such as indomethacin, aspirin, coumarin, etc. When thrombocytopenia or thrombocytopenia occurs, skin purpura and mucosal bleeding may occur, and in severe cases, internal bleeding may occur.

Henoch-Schonlein purpura

Due to allergy to certain drugs, the permeability and fragility of the capillary walls increase, causing allergic purpura, which often manifests as skin purpura, and may also be accompanied by symptoms such as abdominal pain and joint pain. The more common drugs include antibiotics, sulfonamides, antipyretic and analgesic drugs such as streptomycin, isoniazid, aspirin, and metamizole.