Furosemide tablets instructions

There are many types of diseases that can be treated with furosemide tablets, the typical ones being edema-type diseases, such as cirrhosis, kidney disease, congestive heart failure, etc. Drugs are often used in combination, and a single drug cannot achieve the best effect. Therefore, you must be cautious when using furosemide tablets and read the instructions for furosemide tablets carefully, especially some adverse reactions, which are what patients need to pay most attention to.

[Drug name] Generic name: Furosemide Tablets English name: Furosemide Tablets

【Ingredients】 The main ingredients of this product are: furosemide. Its chemical name is: 2-[(2-furanylmethyl)amino]-5-(sulfamoyl)-4-chlorobenzoic acid.

[Indications] 1. Edema diseases include congestive heart failure, liver cirrhosis, kidney disease (nephritis, nephropathy and acute and chronic renal failure caused by various reasons), especially when other diuretics are ineffective, the use of this type of drug may still be effective. Used in combination with other drugs to treat acute pulmonary edema, acute cerebral edema, etc. 2. Hypertension In the step therapy of hypertension, it is not the first choice drug for the treatment of primary hypertension, but it is particularly suitable when thiazide drugs are ineffective, especially when accompanied by renal insufficiency or hypertensive crisis. 3. Prevention of acute renal failure. It is used for insufficient renal blood perfusion due to various reasons, such as dehydration, shock, poisoning, anesthesia accidents and circulatory insufficiency. Timely application while correcting the insufficient blood volume can reduce acute tubular failure. [Usage and Dosage] Adults: (1) Treatment of edematous diseases. The initial dose is 20-40 mg orally once a day. If necessary, an additional 20-40 mg can be taken after 6-8 hours until a satisfactory diuretic effect occurs. Although the maximum dose can reach 600 mg per day, it should generally be controlled within 100 mg and taken in 2 to 3 times. To prevent excessive diuresis and adverse reactions. For some patients, the dosage can be reduced to 20-40 mg, taken once every other day, or taken continuously for 2-4 days per week, 20-40 mg per day. (2) Treat hypertension. Initially, take 40 to 80 mg per day in 2 divided doses and adjust the dose as appropriate. (3) Treatment of hypercalcemia. Take 80-120 mg orally daily, divided into 1-3 doses. Children: For the treatment of edema, initially take 2 mg/kg body weight orally, and if necessary, add 1 to 2 mg/kg every 4 to 6 hours. The interval between medications should be extended for newborns.

[Adverse Reactions] Common adverse reactions are related to water and electrolyte disorders, especially when used in large doses or for long periods of time, such as orthostatic hypotension, shock, hypokalemia, hypochloremia, hypochloremic alkali poisoning, hyponatremia, hypocalcemia, and related thirst, fatigue, muscle aches, arrhythmias, etc. Rare cases include allergic reactions (including rash, interstitial nephritis, and even cardiac arrest), blurred vision, xanthoopia, photosensitivity, dizziness, headache, sodium difference, nausea, vomiting, abdominal pain, diarrhea, pancreatitis, muscle rigidity, etc., bone marrow suppression leading to granulocytopenia, thrombocytopenic purpura and aplastic anemia, liver damage, paresthesia of fingers (toes), hyperglycemia, positive urine sugar, aggravation of existing diabetes, and hyperuricemia. Tinnitus and hearing impairment are more common during rapid intravenous injection of large doses (doses greater than 4 to 15 mg per minute). Most of them are temporary, and a few are irreversible, especially when used simultaneously with other ototoxic drugs. Hypercalcemia may cause kidney stones. There are also reports that this drug can aggravate idiopathic edema.

[Taboo] Not clear yet

【Precautions】 (1) Cross-allergy. People who are allergic to sulfonamides and thiazide diuretics may also be allergic to this drug. (2) Interference with diagnosis: It can cause increased blood sugar and positive urine sugar, especially in patients with diabetes or prediabetes. Excessive dehydration can cause a temporary increase in blood uric acid and urea nitrogen levels. Blood Na+, Cl-, K+, Ca2+ and Mg2+ concentrations decreased. (3) Use with caution in the following situations: ① Patients with anuria or severe renal impairment. Since the latter requires a higher dose, the interval between medications should be extended to avoid side effects such as ototoxicity; ② Diabetes; ③ Hyperuricemia or a history of gout; ④ Severe liver damage, as water and electrolyte imbalance may induce hepatic coma; ⑤ Acute myocardial infarction, as excessive diuresis may induce shock; ⑥ Pancreatitis or a history of this disease; ⑦ Patients with a tendency to hypokalemia, especially those using digitalis drugs or with ventricular arrhythmias; ⑧ Lupus erythematosus, as this drug may aggravate the condition or induce activity; ⑨ Prostatic hypertrophy. (4) Follow-up examinations: ① Blood electrolytes, especially for patients taking digitalis or corticosteroids or with impaired liver and kidney function; ② Blood pressure, especially for antihypertensive drugs, high-dose drugs or for the elderly; ③ Renal function; ④ Liver function; ⑤ Blood sugar; ⑥ Blood uric acid; ⑦ Acid-base balance; ⑧ Hearing. (5) The drug dosage should start with the minimum effective dose and then be adjusted according to the diuretic response to reduce the occurrence of side effects such as water and electrolyte disorders. (6) When hypokalemia or a tendency to hypokalemia exists, potassium salt supplementation should be taken. (7) When used in combination with antihypertensive drugs, the dosage of the latter should be adjusted as appropriate. (8) Patients with oliguria or anuria should stop taking the drug if the drug is still ineffective 24 hours after taking the maximum dose.

[Use in special populations] Precautions for children: The half-life of this drug is significantly prolonged in newborns, so the dosing interval for newborns should be extended.

Precautions during pregnancy and lactation: 1. This drug can pass through the placental barrier, and pregnant women, especially in the first 3 months of pregnancy, should try to avoid using it. It has no preventive effect on pregnancy-induced hypertension syndrome. Animal experiments show that this product can cause fetal hydronephrosis, miscarriage and increased fetal mortality.

2. This drug can be secreted through breast milk and should be used with caution by lactating women.

Precautions for the elderly: Elderly people are more likely to experience hypotension, electrolyte imbalance, thrombosis and renal damage when using this drug.