High immature granulocyte ratio

When the percentage of immature cells increases in a routine blood test, it is necessary to determine what type of cells they are and conduct a comprehensive analysis based on the clinical symptoms. Recheck the routine blood test, provide detailed test data, especially white blood cells and classification, and perform manual white blood cell classification on the blood smear to observe whether there are abnormal white blood cells. Moreover, in these processes, sometimes the ratio of immature granulocytes will be high, so let's take a look at this situation below!

The mononuclear phagocyte system (MPS), which includes promonocytes in the bone marrow, monocytes in the peripheral blood, and macrophages in the tissues, is one of the cell types with the most active biological functions in the body. MPS is derived from bone marrow hematopoietic stem cells. Under the action of certain factors, hematopoietic stem cells in the bone marrow microenvironment continuously enter the bloodstream, accounting for about 1-3% of the total peripheral blood cells. They only stay in the blood for a few hours to a few days, then migrate through vascular endothelial cells to various tissues and organs throughout the body and develop into mature macrophages.

1. The main function is: immunity. 2. Reference values for white blood cell classification counts : Percentage of neutrophil band granulocytes (%): 1-5 Absolute value (×10 to the 9th power): 0.04-0.5 Neutrophil segmented granulocytes 50-70 2-7 Eosinophils 0.5-5 0.02-0.5 Alkaliphils 0-1 0-0.1 Lymphocytes 20-40 0.8-4 Monocytes 3-8 0.12-0.8 3. Clinical significance of monocytes: An increase in monocytes is seen in certain infections and certain blood diseases, while a decrease in monocytes is of little significance.

4. Immature granulocyte types include metamyelocytes, myelocytes and promyelocytes. Their appearance in peripheral blood is an important information of enhanced bone marrow hematopoietic function, destruction of the myeloid-blood barrier or the emergence of extramedullary hematopoiesis. It is an important parameter for clinical diagnosis, treatment monitoring and prognosis of diseases such as inflammation, blood diseases, infectious diseases and sepsis in adults and infants. The reference value range of absolute IG value and IG percentage of the laboratory should be established for healthy people regardless of gender and age: absolute IG value: 95% confidence interval for men is (0, 0.04×109/L); for women is (0, 0.02×109/L). IG percentage: 95% confidence interval for males is (0, 0.5%); for females it is (0, 0.4%)

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