The efficacy of leech hormone

Leeches, commonly known as leeches, are effective in preventing cardiovascular and cerebrovascular diseases and cancer. It grows and breeds in inland waters. It is a traditional aquatic organism with special medicinal value in my country. Its dried product is used as medicine after traditional Chinese medicine processing. The natural ecological resources are depleted. With the in-depth development of the functions and effects of leeches, its market demand development potential is huge. It has the functions of treating stroke, hypertension, blood stasis, amenorrhea, and trauma.

1. Hirudin contained in fresh leech salivary glands is an active polypeptide composed of a variety of amino acids with an isoelectric point of pH 3.8, and is relatively stable to inversion reactions; the pure product is dark gray or milky white scales or powder, and is easily spoiled by heat or in dilute alkali. The hirudin in dried Chinese medicinal materials has been destroyed. In addition, it also contains heparin and antithromboxane.

2. Anti-early pregnancy effect It has the effect of terminating pregnancy in every stage of pregnancy, including embryo implantation and early, middle and late stages, but it is most effective in early pregnancy; if exogenous progesterone is injected together with leeches, the anti-early pregnancy effect of leeches can be counteracted.

3. Anticoagulant effect: It has a significant inhibitory effect on ADP-induced platelet aggregation, and can reduce the whole blood viscosity and blood viscosity, and shorten the blood cell electrophoresis time; hirudin has a preventive effect on thrombosis caused by bacterial endotoxins, and can reduce the mortality rate; hirudin can also enhance the contraction of paraffin sections induced by antithrombin. In vitro experiments showed that 0.45 g/kg of leech water extract was administered intragastrically 4 hours after administration and continued for 7 days. In vitro experiments showed that 200 mg/ml, 100 mg/ml and 50 mg/ml of leech water extract also had a significant inhibitory effect on normal human platelet aggregation. Hirudin is a thrombin retarder, and each mg of hirudin contains 10 to 400 antithrombin companies with specificity;

4. Promote blood circulation: It can promote the absorption of abscesses caused by acute cerebral hemorrhage, relieve inflammation and edema around the brain tissue, reduce increased intracranial pressure, improve local circulation, and facilitate the recovery of the autonomic nerves; it also has the effect of promoting the absorption of experimental abscesses in the ear.

5. Leeches have a significant effect on reducing cholesterol and triglycerides in experimental hyperlipidemia. Hirudin has an inhibitory effect on tumor cells and has a certain inhibitory effect on the growth and development of liver cancer. Because leeches have high anticoagulant effect, they are beneficial for anti-cancer drugs and immune-specific cells to penetrate cancer tissue and destroy tumor cells.