Is surgery necessary for low-grade tumors?

Low-grade neoplasia is a very common cancer disease. Although this disease is not very serious, it is enough to cause some impact on our body. What we should pay attention to in normal times is the treatment of the disease, and we must do regular and repeated examinations. Surgery can be performed when necessary, but some patients will also choose conservative treatment methods.

Today, a brother had a gastroscopy and the pathology report showed low-grade internal neoplasia. He was very stressed and consulted me. The explanation I give is for reference only.

The carcinogenesis of gastric mucosa is a long and complicated process. Gastric mucosal dysplasia is a precancerous lesion and is closely related to the occurrence of gastric cancer. In 2000, the World Health Organization (WHO) introduced the concept of GIN into its new tumor classification. This classification clearly divides gastric mucosal intraepithelial neoplasia into low-grade intraepithelial neoplasia and high-grade intraepithelial neoplasia according to the degree of cell atypia and structural disorder. LGIN is equivalent to mild and moderate dysplasia of the gastric mucosa; HGIN is equivalent to severe dysplasia and carcinoma in situ, replacing previous terms such as atypical hyperplasia and carcinoma in situ.

Low-grade intraepithelial neoplasia refers to architectural and cytological abnormalities limited to the lower half of the epithelium and is equivalent to mild and moderate dysplasia. High-grade intraepithelial neoplasia refers to the extension of structural and cytological abnormalities to the upper half of the epithelium or even the entire layer, which is equivalent to severe dysplasia and carcinoma in situ. Those carcinomas that lack morphologic evidence of invasion into the submucosal layer are classified as high-grade intraepithelial neoplasia. High-grade intraepithelial neoplasia has biological characteristics similar to those of tumor cells and has the potential to develop into tumor cells, but it is still a benign lesion. Appropriate intervention measures can stop or even reverse its development. It is suggested that the name high-grade intraepithelial neoplasia is more appropriate than adenocarcinoma in situ, and intramucosal neoplasia is more appropriate than intramucosal adenocarcinoma. The purpose is to avoid overtreatment and prevent unnecessary damage to the human body that affects prognosis and quality of life.

To summarize, it is not cancer at present, but it has a tendency to develop and can be reversed by treatment. Regular review is required.