What is ichthyosis?

Ichthyosis is usually a chromosomal problem and has a certain chromosomal dominant inheritance, but it does not mean that patients without ichthyosis in the family will not develop the disease. In fact, the occurrence of ichthyosis can cause the patient's skin to become ill from an early age and gradually become hardened, requiring daily application of medicine to recover, and the treatment of ichthyosis is also very complicated.

Among the types of ichthyosis, the most common are autosomal dominant ichthyosis vulgaris and sex-linked ichthyosis vulgaris.

Inheritance of autosomal dominant ichthyosis vulgaris is characterized by the following:

1. Since the disease-causing gene is located on the autosome, inheritance has nothing to do with gender, which means that both men and women can get the disease and have equal chances;

2. One of the patient's parents must be a patient, but most are heterozygous (that is, only one of the paired chromosomes is abnormal), and there is about a 1/2 chance that the patient's siblings will also become patients;

3. The continuous transmission of this disease can be seen in the family pedigree, that is, patients can usually be seen in several consecutive generations. Of course, due to the one-child policy in our country, this situation may not be typical at present.

4. When both parents are healthy, their children generally will not get sick.

The inheritance pattern of sex-linked ichthyosis vulgaris is recessive.

1. The most common occurrence in a sex-linked ichthyosis family is when a normal gene carrier female marries a normal male. Half of the sons will be affected and half of the daughters will be carriers of the gene abnormality.

2. When a male patient marries a normal woman, all sons and daughters appear normal, but the father's abnormal X gene must be passed on to the daughter, so all daughters are carriers of the gene abnormality. The inheritance of sex-linked ichthyosis vulgaris has the following characteristics:

1. There are far more male patients than female patients in the population, and there are often only male patients in a family;

2. If both parents are healthy, the son may develop the disease, but the daughter will not; if the son develops the disease, the mother must be a carrier, and the daughter also has a 1/2 chance of being a carrier;

3. The male patient's brother, grandfather, uncle, cousin, nephew, etc. may also be a patient;

4. If a woman is a patient, her father must be a patient and her mother must be a carrier.

According to the characteristics of genetics, if a man is suffering from sex-linked ichthyosis, it is best to choose to have a boy, so that the inheritance of offspring can be cut off and future children will no longer suffer from the pain of inheritance. If there is a patient with sex-linked ichthyosis in the female's family, it is recommended that the woman go to the relevant medical department for prenatal consultation and testing during pregnancy. If the girl is a carrier of the gene or the male is found to have an abnormal gene, the pregnancy can be terminated. There is only one pair of sex chromosomes, which have been studied extensively. The genetic abnormalities of sex-linked ichthyosis have also been basically located, and medical departments are now conducting prenatal testing research.