Causes of high uric acid

Polarized light is a common urinary tract disease. If there is too much of it, it will cause some urinary stones or gout symptoms, so it must be treated and diagnosed in time in daily life. The main reason is the imbalance between the production and exhaust volume of uric acid in the body. The high uric acid level is mainly caused by gout. In addition, when suppressing the high uric acid level, you must choose some natural and non-irritating foods to treat uric acid.

The main reason for high uric acid level is that the secretion of some glomeruli and renal tubules is inhibited or some other types of diseases lead to kidney deficiency. If uric acid level is high, you must do some proper exercise and drink more boiled water in your daily life, eat less meat and be a vegetarian, and avoid spicy food, tobacco, and alcohol.

In patients with hyperuricemia and gout, when given different uric acid loads, the ratio of urate clearance to glomerular filtration rate is lower than that in normal people. The decrease in uric acid secretion may be related to a decrease in glomerular filtration rate, decreased tubular secretion, or tubular reabsorption. Although high uric acid levels are always present in chronic kidney disease, the relationship between uric acid concentration and serum creatinine and blood urea nitrogen is still unclear.

As renal function declines, the amount of uric acid secreted per unit glomerulus increases, but the secretion capacity of the renal tubules remains basically unchanged, the reabsorption capacity of the renal tubules also decreases, and the ability to clear uric acid outside the kidney increases significantly.

1. Inhibition of renal tubular secretion: one of the most important mechanisms. Inhibition of uric acid excretion and/or increased reabsorption due to drugs, intoxication, or endogenous metabolites. This occurs when anion transport systems are inhibited, two important inhibitors of which are lactate and keto acids.

2. Reduced glomerular filtration: It can also increase uric acid levels. One of the mechanisms is reduced filtration rate, which is the main cause of hyperuricemia in renal insufficiency or failure. Increased net uric acid reabsorption can occur in the setting of volume depletion and is one of the mechanisms by which diuretics may induce hyperuricemia.

3. Increased tubular reabsorption: Hyperuricemia can also be caused by enhanced reabsorption distal to the secretion site. These may occur with dehydration or diuretic therapy in patients with diabetes.

The above are the reasons for high uric acid levels. It is mainly caused by an imbalance between the amount of uric acid produced and the amount of gas discharged in the body. The high uric acid level is mainly caused by gout. In addition, when suppressing high uric acid levels, you must choose some natural and non-irritating foods to treat uric acid. You must avoid eating spicy and irritating foods, and you must pay attention to light and hygienic diet. .