What causes ankylosing spondylitis?

Ankylosing spondylitis is a common chronic disease that is very harmful to patients. Patients suffer a lot when they suffer from this disease. There are many causes of ankylosing spondylitis, and it has an important relationship with genetics. In addition, some viral infections are also important causes of ankylosing spondylitis. For example, prostate seminal vesiculitis can be transmitted to the sacroiliac joint through lymphatic tissue, thereby leading to the occurrence of spondylitis.

Causes of ankylosing spondylitis:

The exact cause of ankylosing spondylitis is not yet known. Medical experts speculate that it is an autoimmune disease, that is, the body's immune system attacks the body's own tissues, leading to the onset of ankylosing spondylitis inflammation. More than 90% of patients with ankylosing spondylitis have HLA B27- histology. However, only 8% of the general population in Europe is found to have HLA B27- tissue phenomenon, so it can be said that ankylosing spondylitis is determined by genes, which is the cause of ankylosing spondylitis.

1. Genetic factors:

Ankylosing spondylitis has a stronger familial tendency than rheumatoid arthritis. Its family aggregation degree is about 40. Among AS patients whose first-degree relatives are HLA-B27 positive, about 51% are HLA-B27 positive.

2. Infection factors:

Some people believe that genitourinary tract infection is an important factor causing ankylosing spondylitis. Most male patients suffer from prostate seminal vesiculitis, and the infection may spread to the sacroiliac joints through the lymph or veins, then to the spine, and may also spread to the general circulation to cause systemic symptoms and lesions of surrounding joints, tendons, etc.

3. Disease factors:

During the course of the disease, cartilage transforms into bone at the site of spinal joint inflammation. After this process, the pain in the joints will be significantly reduced. Due to the solidification and cartilage degeneration of the spinal joints in patients with ankylosing spondylitis, the overall mobility of the spine is restricted, and the movement of the spine is limited to a certain range. The serious thing is that this process is difficult to recover. X-rays and magnetic resonance imaging can be used to confirm the progression and location of ankylosing spondylitis. Therefore, this is also a cause of ankylosing spondylitis.

4. Other factors:

Trauma, parathyroid disease, tuberculosis, lead poisoning, upper respiratory tract infection, gonorrhea, local suppurative infection, endocrine and metabolic defects, allergies, etc. can all be the causative factors of this disease, but the evidence is insufficient and needs to be further studied and confirmed.

Warm reminder: The above content is a detailed introduction to the causes of ankylosing spondylitis. I hope it will be helpful to you, my fellow patients. Expert Tip: Based on this knowledge of the causes of the disease, patients can take very effective treatments and recover soon. Therefore, patients with ankylosing spondylitis should not miss the best treatment time, which will cause you unnecessary pain.