Glutamine transpeptidase

Everyone should know that the reason why our human body can survive is entirely due to the cooperation of many aspects, such as; a normal brain, even breathing, strong heartbeat and blood flow. These are all indispensable, because if there is a problem in any link, it will seriously affect our life. But in addition to these, there are often some substances that the human body relies on for survival, such as water and some trace elements. When the human body lacks these, it often does not immediately affect life, but it will also have abnormal manifestations.

In fact, in addition to those introduced above, there are many things that are indispensable to the human body. If certain aspects of the body's functions are lacking, they will be affected, and even related diseases may occur, such as: glutamine transpeptidase. When it comes to glutamine transpeptidase, you may not be very clear about it, so let me introduce it in detail below.

Glutamine transpeptidase is widely distributed in human tissues, with the highest concentration in the kidney, followed by the pancreas and liver. During the embryonic period, it is most abundant in the liver, where it is mainly distributed in the hepatocyte cytoplasm and intrahepatic bile duct epithelium. γ-GT in normal human serum mainly comes from the liver. The normal value is 3-50U/L (γ-glutamyl-p-nitroaniline method). This enzyme is only slightly or moderately elevated in acute hepatitis, chronic active hepatitis and decompensated cirrhosis. However, in obstructive jaundice, this enzyme flows back into the blood due to excretion disorder. In primary liver cancer, the synthesis of this enzyme in the liver is hyperactive, both of which can cause a significant increase in blood transpeptidase, even to more than 10 times the normal level. γ-GT is also significantly elevated in alcoholics, which helps in the diagnosis of alcoholic liver disease.

Glutamine transpeptidase is present in tissues such as the kidney, pancreas, liver, spleen, intestine, brain, lung, skeletal muscle and myocardium. In the liver, it is mainly present in the hepatocyte cytoplasm and intrahepatic bile duct epithelium. Glutamyl transpeptidase lacks specificity for the diagnosis of hepatobiliary diseases. Elevated serum levels not only indicate hepatobiliary diseases, but are also seen in diseases other than the liver, such as acute pancreatitis, congestive heart failure, myocardial infarction, and diabetes.

The activity of glutamyl transpeptidase was well consistent with the level of transaminase and the degree of liver lesions. Increased glutamyl transpeptidase was positively and linearly correlated with transaminase. The abnormal rate of glutamyl transpeptidase is significantly correlated with the degree of liver tissue lesions, so glutamyl transpeptidase can also be regarded as an indicator reflecting the degree of liver cell damage.

Now that we have learned so much about glutamine transpeptidase, I believe that if similar situations occur in our daily lives in the future, we will not panic. We should treat it with a good and positive attitude and go to the hospital for diagnosis and treatment as soon as possible. In addition, you should also pay attention to the balance of life and diet, and exercise more.