Treatment of viral hepatitis

Viral hepatitis is a hepatitis disease caused by a virus, often accompanied by symptoms of nausea, fatigue, and liver pain. In severe cases, it can develop into cirrhosis, and even worse, liver cancer. Viral hepatitis is divided into five types, each caused by a different viral infection. Let's take a look at the treatment methods for viral hepatitis.

1. General treatment

During the active stage of acute hepatitis and chronic hepatitis, hospitalization, bed rest, proper nutrition, and guaranteed supply of calories, protein, and vitamins are required. Alcohol is strictly prohibited, and activities should be gradually increased during the recovery period. During the dormant period of chronic hepatitis, you can do work within your ability. For severe hepatitis, you must stay in bed and try to reduce the protein in your diet, while ensuring calories and vitamins. You can receive transfusions of serum albumin or fresh plasma to maintain a stable water and electrolyte balance.

2. Antiviral treatment

Acute hepatitis generally does not require antiviral treatment. Early use of interferon is recommended only in acute hepatitis C to prevent chronicity, while chronic viral hepatitis requires antiviral treatment. ① Interferon: Recombinant DNA leukocyte interferon (IFN-α) can inhibit the replication of HBV. Only 30% to 50% of patients achieve lasting effects after intramuscular injection every other day for 6 consecutive months. The drug of choice for hepatitis C is interferon, which can be used in combination with ribavirin. ② Lamivudine: It is a synthetic dideoxycytidine nucleoside drug with anti-HBV effect. Oral administration of lamivudine can significantly reduce serum HBV-DNA levels, and the HBV-DNA negative conversion rate reaches more than 90% after 12 weeks of medication. Long-term use of the drug can reduce ALT and improve liver inflammation, but the HBeAg negative conversion rate is only 16% to 18%. HBV mutations may occur after treatment for more than 6 months, but the drug can still be continued. If the side effects are mild, it can be continued for 1 to 4 years. ③Famciclovir: It is a guanosine drug with a long half-life and high intracellular concentration, which can inhibit the replication of HBV-DNA. This drug has mild side effects and can be used in combination with lamivudine, interferon, etc. to improve efficacy. ④ Other anti-disease drugs: such as acyclovir, adefovir, sodium foscarnet, etc. all have a certain effect in inhibiting HBV.

3. Immunomodulators

Commonly used ones are: ① Thymosin α1 (Zidaxin) has a bidirectional immunoregulatory effect and can restore the immune function of patients with primary and secondary immunodeficiency. ② Thymosin

Participate in the immune response of the body's cells, induce the differentiation and maturation of T lymphocytes, amplify the response of T cells to antigens, and regulate the balance of various T cell subpopulations. ③Immune RNA can induce interferon in the body and enhance the body's immune function.

4. Guided treatment

New immunotherapies (such as DNA vaccine immune complex therapy, etc.) and gene therapies (antisense nucleic acid therapy and transgenic therapy) are under research.

5. Liver protection drugs

Liver protecting drugs: ① Hepatocyte growth factor promotes liver cell regeneration, has a protective effect on liver cell damage, and can regulate the body's immune function and anti-fibrosis effects. ② Silybin has the function of protecting and stabilizing liver cell membranes. ③ Diammonium glycyrrhizinate (Glycyrrhizin) has strong anti-inflammatory, cell membrane protection and liver function improvement effects. It is suitable for chronic persistent hepatitis and chronic active hepatitis accompanied by elevated alanine aminotransferase. ④Adenosylmethionine (Simetai)

Supplementation of exogenous adenosylmethionine can promote the disappearance of jaundice and the recovery of liver function.

The liver is particularly important to our human body. It is our main organ for detoxification, so the health of the liver is directly related to the health of the body. It is recommended that everyone pay more attention to their body, take good care of their liver, drink less, avoid large emotional fluctuations, and the public should actively get vaccinated to avoid being invaded by the hepatitis virus and causing liver disease.