Splenic marginal zone lymphoma

Slippery is a very serious disease problem because cancer is usually a transformation of a tumor. In life, people do not pay attention to their diet structure and are often prone to diseases. Therefore, the human spleen and stomach are very important and must be well protected. However, if severe lymphoma occurs, care should be taken to avoid transformation. So what should we do about splenic marginal zone lymphoma?

Classification

Lymphoma is divided into diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL), angioimmunoblastic T-cell (AITCL), primary central nervous system lymphoma (PCNSL), T/NK-cell lymphoma (NK/TCL), follicular NHL lymphoma (FL)

Gastric MALT lymphoma, non-gastric MALT lymphoma (NGMLT), splenic marginal zone B-cell lymphoma (SPLN), anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma (CTCL).

pathology

Splenic marginal zone cell lymphoma

Splenic marginal zone cell lymphoma Splenic marginal zone lymphoma (SMZL) is a new independent type formally defined in the "WHO 2000 classification of hematopoietic and lymphoid tissues". It is a low-grade malignant B-cell lymphoma originating in the spleen. Due to the small number of reported cases, the understanding of the disease is still incomplete. There is only one report in China that describes the clinical and tumor cell characteristics. Marginal zone B-cell lymphoma includes three pathological types: extranodal mucosa-associated lymphoma, nodal marginal zone B-cell lymphoma, and splenic marginal zone B-cell lymphoma. The three pathological types have distinct clinical characteristics and different prognoses, and the treatment principles are also different. Early extranodal mucosal splenic marginal zone cell lymphoma

Splenic marginal zone cell lymphoma is mainly treated with radiation therapy.

In the REAL classification, marginal zone B-cell lymphoma is considered to be a B-cell-derived NHL with obvious clinical and pathological features, which includes extranodal marginal zone B-cell lymphoma (MALT-type indolent B-cell lymphoma) and intranodal marginal zone B-cell lymphoma. The latter has been described as monocytic B-cell lymphoma, and recent studies have shown that nodal and extranodal marginal zone B-cell lymphomas have different morphological, immunophenotypical, and clinical features. The morphology and clinical features of splenic marginal zone B-cell lymphoma are significantly different from the previous two. Therefore, nodal marginal zone B-cell lymphoma and splenic marginal zone B-cell lymphoma are included as a suggested category in the REAL classification. In the new WHO classification, marginal zone B-cell lymphoma is divided into three independent pathological types: extranodal marginal zone B-cell lymphoma of MALT type, lymph node MZCL, and splenic MZCL. Marginal zone cell lymphoma:

1. Extranodal: low-grade B-cell mucosa-associated lymphoma.

2. Intranodal: monocytic B-cell lymphoma.