Does high prolactin affect pregnancy?

In life, many people are often diagnosed with high prolactin during the process of examination in the hospital. High prolactin is a human hormone disease, which will cause multiple effects on the patient's body physiology. High prolactin will mostly affect the pregnancy function, because it will first affect ovulation and cause amenorrhea. The patient's pregnancy function is often damaged, and severe cases may also cause tumors.

Influencing factors 1. Nerve stimulation: Irritation of certain parts of the skin, especially the chest, including severe pain caused by peripheral nerve damage, can be transmitted to the hypothalamus through nerves and cause an increase in prolactin. Such as chest surgery, burns, shingles on the chest and back, etc.

2. Pituitary disorders : mainly various tumors in the pituitary area. In addition, some cases of empty sella syndrome and hyperpituitarism can also cause galactorrhea and amenorrhea.

3. Drug factors: Sedatives that act on the central nervous system, such as chlorpromazine, morphine, etc., can reduce the content of catecholamines in the hypothalamus, thereby reducing the activity of prolactin-releasing factor produced by the hypothalamus. Antihypertensive drugs such as methyldopa and reserpine can inhibit the release of prolactin inhibitory factor. Metoclopramide can stimulate excessive secretion of prolactin from the pituitary gland.

4. Primary hypothyroidism: When the thyroid function is hypothyroid, the information of insufficient thyroid secretion is transmitted to the hypothalamus through feedback, causing the hypothalamus to produce a large amount of thyrotropin-releasing factor. This factor, while stimulating the pituitary gland to secrete thyroid-stimulating hormone, can also stimulate the excessive secretion of pituitary prolactin and cause galactorrhea.

5. Hypothalamic disorders: Diseases of the hypothalamus and adjacent areas, such as encephalitis, craniopharyngeal tumor, pineal tumor, partial hypothalamic infarction, pseudotumor cerebri, pituitary stalk transection, etc., can cause a decrease in prolactin-inhibiting factor produced by the hypothalamus, or an increase in prolactin-releasing factor and thyroid-stimulating hormone-releasing factor. The former can cause prolactin to be produced blindly due to the loss of inhibition, while the latter two directly promote the increase of prolactin production.

Related diseases

1. Infertility

2. Galactorrhea-amenorrhea syndrome (amenorrhea-galactorrhea and decreased follicle-stimulating hormone syndrome; amenorrhea-galactorrhea syndrome; pituitary prolactinoma; Forbes-Albringt syndrome)

3. Galactorrhea (lactorrhea-amenorrhea syndrome; milk leakage; abnormal milk secretion syndrome; galactorrhea; lactorhea)

4. Subclinical hypothyroidism (mild hypothyroidism; latent hypothyroidism; biochemical hypothyroidism; decreased thyroid reserve; subclinical hypothyroidism; subclinical hypothyroidism; subclinical hypothyroidism)