Venous sinus thrombosis is a relatively common cerebrovascular disease. Although its incidence rate is not particularly high, the harm is indeed very great, especially for children. It may cause relatively serious effects, often causing edema in children, causing damage to neurons, and easily causing punctate bleeding. Generally, it will not cause ventricular dilation and will not cause children to develop symptoms of hydrocephalus. Clinical symptoms To better understand the clinical symptoms and signs of CVST, two different pathophysiological mechanisms should first be distinguished. That is, cerebral venous thrombosis - focal symptoms caused by venous obstruction; cerebral venous sinus thrombosis - intracranial hypertension caused by venous sinus thrombosis. In most patients, these two pathophysiological processes often exist simultaneously. Occlusion of cerebral veins produces localized cerebral edema and venous infarction. Pathological examination may reveal enlarged, swollen veins, edema (including cytotoxic edema and vasogenic edema), ischemic neuronal damage and punctate hemorrhages. The latter can fuse into a large hematoma and be detected by CT. Transverse sigmoid sinus thrombosis can lead to increased venous pressure, thereby affecting the absorption of cerebrospinal fluid and causing intracranial hypertension. Because the disease affects the final pathway of cerebrospinal fluid circulation, there is no pressure gradient between the subarachnoid space and the ventricles, so the ventricles do not expand and will not cause hydrocephalus in all patients. Causes of sinus thrombosis 1. General manifestations The manifestations of inflammatory intracranial venous thrombosis are divided into systemic symptoms, symptoms of local infection foci and sinus symptoms. Systemic symptoms include irregular high fever, chills, fatigue, muscle aches, mental depression, subcutaneous congestion and other symptoms of infection and sepsis. Non-inflammatory intracranial venous thrombosis mainly includes symptoms of causes and risk factors and sinus symptoms. 2. The clinical manifestations of intracranial venous sinus thrombosis lack specificity, and its symptoms and signs vary. The onset may be acute or slow over several weeks. The most common symptoms include headache, focal neurological deficits, epileptic seizures, impaired consciousness, and optic disc edema. Some authors have proposed the following types of manifestations: (1) Progressive increase in intracranial pressure. (2) Sudden onset of focal neurologic damage that mimics an arterial stroke but without the presence of an epileptic seizure. (3) Focal neurologic lesions with or without epileptic seizures and increased intracranial pressure that progress over a few days. (4) Focal lesions of the nervous system with or without epileptic seizures and increased intracranial pressure that progress over weeks or months. (5) Sudden onset of headache, similar to subarachnoid hemorrhage or transient ischemic attack 3. Clinical manifestations of cerebral venous thrombosis Simple cerebral venous thrombosis is rare and most cases are caused by the extension of venous sinus thrombosis. (1) Superficial vein thrombosis often presents suddenly with symptoms such as headache, vomiting, optic disc edema, localized epileptic seizures, limb paralysis, and cortical sensory disturbances, which are signs and symptoms of increased intracranial pressure and localized cortical damage. (2) Deep vein thrombosis is also clinically non-specific, with the main manifestations being headache, mental disorders, and impaired consciousness. Mild hemiplegia, pyramidal tract signs, and decorticate rigidity or decorticate state may also occur. Optic disc edema is rare. |
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