Precautions after penicillin injection

Penicillin is a relatively common hormone that can relieve many abnormal manifestations of the human body. However, when injecting penicillin, everyone should understand some conditioning measures to promote the body's absorption and reduce the negative harm of penicillin to the human body. The following are the precautions after injecting penicillin. I hope it can help everyone use penicillin rationally and maximize the effectiveness of penicillin.

1. Avoid using it with alkaline drugs when taking it orally or by injection to avoid decomposition and ineffectiveness.

2. This product should not be mixed with tetracycline hydrochloride, kanamycin, polymyxin E, sulfadiazine sodium, adenosine triphosphate, coenzyme A, etc. for intravenous drip to avoid precipitation or reduction of efficacy.

3. Chloramphenicol and penicillin should generally not be used in combination, because chloramphenicol is an antibacterial agent, while penicillin is a bactericide during the reproductive period. Their combined use may affect the antibacterial activity of penicillin and reduce its efficacy. However, this issue is still controversial and opinions vary, because the combination of the two has good clinical effects on mixed infections of Gram-positive and Gram-negative bacteria and intracranial infections. The solution is that if combined use is necessary, it is advisable to use penicillin 2 to 3 hours before using chloramphenicol.

4. Since this product can inhibit the activity of certain liver enzymes, it can interfere with the biotransformation of tolbutamide, phenytoin sodium and dicoumarol in the human body, enhance the effects of tolbutamide and phenytoin sodium, and enhance the anticoagulant effect of dicoumarol and warfarin.

5. Use with caution in infants, patients with impaired liver and kidney function, pregnant women in late pregnancy, and avoid use in lactating women.

In addition to doing a skin test before using penicillin, you should also pay attention to the following points:

1. Penicillin injections should be received at a regular medical institution with rescue equipment so that if an allergic reaction occurs, timely and effective rescue treatment can be provided. If you experience dizziness, palpitations, sweating, difficulty breathing or other discomfort at any time during the injection process, tell your doctor or nurse immediately.

2. After the penicillin injection, you need to stay in the hospital for at least 20 minutes for observation and leave only if you feel no discomfort.

3. Do not use penicillin when you are extremely hungry to prevent the body's tolerance to the drug from decreasing when the stomach is empty, inducing adverse reactions such as needle sickness.

4. The two injections should not be given too close together, preferably 4-6 hours apart. When giving intravenous penicillin, do not start too fast; no more than 40 drops per minute is appropriate. Observe for 10-20 minutes to see if there are any adverse reactions and then adjust the infusion speed.

5. If you have a history of penicillin injection on that day and experience dizziness, palpitations, sweating, difficulty breathing and other discomforts at home, you should go to the hospital for diagnosis and treatment in time.