Why do I have frequent urination and painful urination after bladder instillation?

Bladder instillation is a relatively common treatment method. It is often used for bladder cancer. Instilling chemotherapy drugs into the bladder has an auxiliary effect in treating bladder cancer. When performing bladder instillation, you should be aware of some precautions. It may cause patients to experience some uncomfortable symptoms, such as nausea and vomiting. At this time, you should promptly emphasize nutrition and improve the patient's immune ability.

Why do I have frequent urination and painful urination after bladder instillation?

Intravesical instillation therapy is very common in clinical practice. It mainly uses a catheter to directly infuse drugs into the bladder, ureter, urethra, and rectum to achieve therapeutic and preventive effects. This method is mainly used to treat bladder cancer, chronic cystitis, interstitial cystitis, etc.

Since some of the drugs injected into the bladder are toxic, after being injected into the bladder, they will damage the normal bladder mucosa while killing the wounds. At the same time, they have a certain lethality to unhealed wounds. Therefore, it is easy to form mucosal damage and bladder inflammation after bladder instillation, which can lead to symptoms such as frequent urination, urgency and pain when urinating. At this time, anti-infection treatment must be carried out immediately and drink plenty of water. If bladder inflammation recurs, bladder instillation must be stopped and instillation should be resumed after the inflammation improves, or instillation drugs with less toxicity should be replaced. Bladder instillations are generally contraindicated during the acute phase of infection. Therefore, if the above symptoms occur after perfusion, immediate treatment must be sought to avoid delaying the disease.

What precautions should be taken during perfusion therapy?

1. After using different drugs for bladder instillation, it may cause symptoms such as fever, bladder irritation, and urethral stenosis. The reason may be that repeated or improper catheterization causes damage to the urethral mucosa. The chemical toxicity of the catheter destroys the normal structure of the urethral mucosa. Regular cystoscopy and repeated intraurethral operations increase the chance of urethral injury. Or the patient's ability to resist infection is reduced, and aseptic operation techniques are not strictly followed during the infusion process, causing urinary tract infection and leading to urethral stenosis. Or it may be caused by high concentration of drug solution directly stimulating the urethral mucosa, causing epithelial cell mutation and submucosal fibrosis.

In order to alleviate side effects, aseptic operation must be strictly performed, a relatively thin and soft catheter must be selected, and it must be fully lubricated with sterile paraffin cotton balls. Rough operation must be avoided. In addition, it is important to prevent the injection of drugs from the catheter when it is not in the bladder, which may stimulate the urethral mucosa and cause urethral stenosis. Before instillation, the patient should be advised to empty the bladder so that the drug solution can be retained in the bladder for 1-2 hours. After instillation, the catheter should be flushed with saline and the outer opening of the catheter should be clamped before removal to prevent the residual drug solution in the catheter from flowing into the urethra and damaging the urethral mucosa.

Second, although infusion therapy concentrates the drugs in one place, reducing the side effects on normal cells in other parts of the body, it is still inevitable. For example, drug infusion for bladder cancer often causes complications such as prostatitis, cystitis, and bladder bleeding in men. The use of chemotherapy drugs will inevitably cause damage to normal cells. During perfusion treatment, the Chinese medicine ginsenoside Rh2 needs to be used to regulate and alleviate the toxic side effects of chemotherapy. When the monomer content of ginsenoside Rh2 is higher than 16%, it can reduce the amount of drugs used and reduce the harm of chemotherapy to the body by producing a synergistic anti-cancer effect with chemotherapy drugs. Or you can try Xihuang Pills. An article reports that Xihuang Pills combined with intravesical chemotherapy can reduce the recurrence rate of bladder tumors, the incidence of adverse reactions, and improve the quality of life.