The role of testosterone propionate

Testosterone propionate has a wide range of effects. Common diseases it treats include decreased libido, aorticism and cryptorchidism in men, menorrhagia, uterine fibroids, endometriosis and other diseases in women, and it is prone to side effects. When we use testosterone propionate, we must understand its main effects and ensure correct use as much as possible. So, what is the role of testosterone propionate? Let’s take a look below.

Function: The effect is the same as testosterone and methyltestosterone, but the effect of intramuscular injection is longer-lasting, and it can be injected once every 2 to 3 days. It is clinically applicable to atestis, cryptorchidism, male hypogonadism; gynecological diseases such as menorrhagia, uterine fibroids; senile osteoporosis and aplastic anemia, etc. It works by stimulating the kidneys to secrete erythropoietin, or by having a direct stimulating effect on the bone marrow. Androgen replacement therapy for primary hypotesticular function; hypoplastic sex organs. Large doses can cause virilization in women, edema, liver damage, jaundice, dizziness, etc. If an allergic reaction occurs, the medication should be discontinued immediately. It is not recommended for patients with liver or kidney dysfunction, prostate cancer and pregnant women. If crystals are precipitated from the injection solution, they can be heated and dissolved before injection. Delayed puberty and dwarfism; various chronic wasting diseases, etc.

Features of Action: This product is first converted into 5α-dihydrotestosterone (5α-dihyrotesterone) in the body, and then binds to the cell receptor, enters the cell nucleus, interacts with chromatin, activates RNA polymerase, and promotes protein synthesis and cell metabolism. In addition, testosterone propionate can stimulate the production and differentiation of red blood cells through erythropoietin. Although this product can be absorbed orally, it will be quickly destroyed in the liver and become ineffective, so it is generally injected intramuscularly. After intramuscular injection of testosterone propionate, it is absorbed slowly and its effect lasts for 2-4 days. In the blood, 98% of testosterone is bound to sex hormone globulin, and only 2% is free. The half-life is 10-20 minutes. After testosterone is inactivated in the liver, its metabolites are androsterone, isoandrosterone and protocholanolone. 90% of them are excreted in the urine in the form of combined with glucuronic acid and sulfate. About 6% of the unconjugated product is excreted through bile, and a small portion of it can still be reabsorbed, forming an enterohepatic circulation.

Drug Use: Promotes the formation, development, and maturation of male sexual organs, counteracts estrogen, and inhibits endometrial growth and ovarian pituitary function. Promote protein anabolism, stimulate bone marrow hematopoietic function, and stimulate the production of blood cells. It is clinically used for male hypogonadism, atestis and cryptorchidism; gynecological diseases such as menorrhagia, uterine fibroids, endometriosis, osteoporosis in the elderly and aplastic anemia in children. Usage and Dosage: Each tablet is 5 mg. For adults, take orally, 1-2 tablets twice a day, or sublingually, one tablet twice a day. Male androgen deficiency: Oral administration: 6-20 tablets per day, maintenance dose: 4-12 tablets per day. For menorrhagia or uterine fibroids: Take 1-2 tablets sublingually, twice a day, for 3-6 months. Aplastic anemia in children: 1-2 mg per kg body weight per day, taken once or in 2 divided doses. Side effects and precautions: Long-term use of more than 60 tablets per month by female patients may cause acne, hirsutism, hoarseness of voice, changes in sexual desire, etc. Use with caution in patients with impaired liver, kidney and heart function. It is contraindicated for patients with prostate cancer, and not for pregnant women or lactating women.