Cerebral amyloid angiopathy

Cerebral amyloid angiopathy is a cerebrovascular disease that the elderly are more likely to suffer from. Its typical symptoms are dementia, cerebral hemorrhage, etc. The principles of treating cerebral amyloid angiopathy are similar to those of other cerebral hemorrhages. Some patients may also experience symptoms of epilepsy and require treatment with anti-epileptic drugs. In short, targeted inhibition is needed according to the patient's specific symptoms to achieve maximum control.

The onset population is more common in the elderly, except for familial CAA. It is age-dependent and increases after the age of 50. 40% are associated with AD, and 82-96% of AD have CAA. Mild CAA often exists in the normal elderly brain without symptoms. Severe CAA can cause repeated multiple lobar hemorrhages, dementia and other neurological syndromes. Intracranial hemorrhages in people over 70 years old account for 15-20%, accounting for 1/3-1/2 of lobar hemorrhages. It is the third cause of spontaneous cerebral hemorrhage after hypertension and aneurysms. CAA is the first cause of secondary SAH in the elderly. Bleeding is often characterized by recurrence and multiple occurrences. 2.9/8. Progressive intracranial hemorrhage Non-traumatic non-hypertensive lobar hemorrhage is first considered

Pathological autoimmune diseases are called "immune vascular diseases" by some people. Localized inflammatory lesions, degeneration and aging of brain tissue change the permeability of arterioles and capillaries, prompting the deposition of amyloid substances in serum in brain tissue and on the walls of blood vessels. Symptoms 1. The most important and serious complication of lobar hemorrhage is that the frontal, parietal, temporal and occipital lobes may be affected, and rarely in the basal ganglia, cerebellum, brainstem, hippocampus, etc. This is different from hypertensive hemorrhage. In recent years, CAA has caused an increase in cerebellar hemorrhage. Bleeding often penetrates the pia mater outwards - secondary SAH, and even penetrates the arachnoid membrane - subdural hematoma. Cerebral amyloid angiopathy (CAA) - clinical manifestations

2. Progressive dementia may also be the only symptom. It develops quickly and worsens progressively over a period of days to years. (The difference from AD) Leukoencephalopathy is a prominent imaging feature of CAA with dementia. Causes of dementia: Leukoencephalopathy + multiple cortical strokes, chronic ischemic damage, epilepsy, stress response, antihypertensive drugs, etc. Cerebral amyloid angiopathy (CAA) - clinical features 3. Cerebral infarction: Infarction is more common in the occipital lobe, posterior temporal lobe, parietal lobe and frontal lobe, but is smaller and milder than general arteriosclerotic cerebral infarction, and can be multiple and recurrent. It is easy to bleed, so anticoagulation and thrombolysis should be used with caution 4. TIA is more common in the internal carotid artery system, but can also be in the vertebral basilar artery system. Anticoagulants and antiplatelets are used, which can easily induce bleeding.

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