What to do if your heart is severely ischemic

If there is severe ischemia in the heart, it will cause great harm to the patient. Various symptoms will often appear, causing the patient to experience palpitations, dizziness, nausea, and more serious heart disease. At this time, certain medications should be used for treatment in time. For example, nitroglycerin can effectively reduce the symptoms of myocardial ischemia. It has the effect of dilating blood vessels and can promote blood circulation. Let us learn about this aspect.

What to do if your heart is severely ischemic

1. Nitroglycerin:

It can reduce myocardial oxygen consumption in patients with myocardial ischemia. Nitroglycerin has the effects of dilating capacitance vessels, reducing the amount of blood returning to the heart, lowering ventricular filling pressure and volume, reducing preload, and reducing ventricular wall tension, thereby reducing myocardial oxygen consumption and releasing endogenous substances that have a direct protective effect on myocardial cells.

2. Perhexiline:

It has the effect of reducing myocardial oxygen consumption and reducing the production of free fatty acids, which can increase the utilization of glucose by ischemic tissues and maintain the capacity supply of ischemic myocardium. It inhibits the uptake of fatty acids by mitochondria by inhibiting carnitine palmitoyltransferase, and transfers the substrate of energy metabolism from fatty acids to glucose, thereby improving myocardial ischemia.

3. Trimetazidine:

Trimetazidine can reduce the frequency of myocardial ischemia and increase the number of myocardial metabolisms, while exerting its therapeutic effects without obvious side effects. In severe myocardial ischemia, trimetazidine reduces the oxidation of free fatty acids and is accompanied by an increase in the rate of glucose oxidation.

4. Nitrates:

Such as isosorbide mononitrate, nitroglycerin and isosorbide mononitrate. Dosage forms include tablets, injections, patches and sprays. The mechanism of nitrates in fighting myocardial ischemia is to reduce preload, afterload and oxygen consumption; change the redistribution of myocardial blood flow, which is beneficial to the perfusion of the ischemic area. However, resistance to these drugs can develop rapidly, which can be reversed after stopping the drug.

5. Calcium antagonists:

Such as nifedipine, hexinshuang, isopreserved and amlodipine. The mechanisms of calcium channel blockers against myocardial ischemia include direct protection of ischemic myocardium; reducing myocardial oxygen consumption and improving myocardial working efficiency; increasing myocardial blood supply to the ischemic area; and promoting the production and release of endogenous nitric oxide. This type of drug has no drug resistance and can reflexively increase heart rate. Some drugs have mild negative inotropic effects.