Side effects of Panax notoginseng saponins

Notoginseng total saponin is an active and effective ingredient extracted from Panax notoginseng. Similar to Panax notoginseng, notoginseng total saponin also has the miraculous effect of promoting blood circulation, removing blood stasis and unblocking meridians in the human body. Many Western doctors make notoginseng total saponin into Western medicine for use as medicine. Notoginseng total saponins can reduce the body's oxygen consumption and improve the body's tolerance to hypoxia. So what are the side effects and effects of Panax notoginseng total saponins? Let’s take a look.

1. Side effects: This adverse reaction mainly occurs in elderly patients. The reason may be that Panax notoginseng and ginseng both belong to the Araliaceae family. From the theory of traditional Chinese medicine, Panax notoginseng and ginseng both have the function of carrying gas upward, replenishing qi and raising yang, which can increase blood pressure.

2. Effects: 1) Anti-myocardial ischemia

Observations on the effects of Panax notoginseng total saponins on experimental myocardial ischemia found that Panax notoginseng total saponins can significantly improve the ischemic manifestations of surface electrocardiogram, reduce the scope of myocardial infarction, reverse left ventricular diastolic dysfunction in patients with exertional angina pectoris, and even restore it to normal.

2) Antiarrhythmic

The observation of the anti-arrhythmia effect of Panax notoginseng total saponins, animal experiments showed that Panax notoginseng total saponins can significantly reduce the experimental ventricular premature beats in rats, significantly shorten the duration of arrhythmia, and significantly reduce the incidence of arrhythmia during reperfusion after acute myocardial infarction in rats.

3) Anti-atherosclerotic effect

Observation of the effect of Panax notoginseng total saponins on diet-induced atherosclerosis in rabbits showed that Panax notoginseng total saponins can play an anti-AS role through anti-inflammatory and antioxidant effects, have a protective effect on vascular smooth muscle cells, protect cells from the influence of high-lipid serum, and have a certain preventive and therapeutic effect on the occurrence and development of atherosclerosis.

4) Anti-thrombosis and improving microcirculation

The effects of Panax notoginseng saponins on ET-1 and platelet function in patients with coronary heart disease were studied. The results showed that Panax notoginseng saponins can significantly reduce platelet surface activity, inhibit platelet aggregation and adhesion, resist thrombosis, and improve microcirculation.

5) Anti-cardiocerebral ischemia effect

Notoginseng total saponins are used to treat cerebral infarction and ischemic cerebrovascular disease. The results show that notoginseng total saponins have a good clinical therapeutic effect on the acute stage of cerebral infarction, and notoginseng total saponins can significantly improve brain edema during global cerebral ischemia or focal ischemia-reperfusion.

6) Promote the growth of hematopoietic cells

Notoginseng total saponins have a proliferative effect on hematopoietic progenitor cells. Studies have also found that Rg1 and Rb1 in Notoginseng total saponins are effective monomers for promoting hematopoiesis, which can continuously promote the proliferation of human bone marrow granulocyte and erythroid hematopoietic progenitor cells, and their effect on granulocyte progenitor cells is better than that on erythroid progenitor cells.