Nitroglycerin tablets

When we hear the name nitroglycerin, we immediately think of heart disease. Yes, nitroglycerin is a drug that heart patients must carry and take regularly. It is very critical for myocardial ischemia and heart disease. However, many people still don’t understand whether nitroglycerin has any side effects and what its clinical applications are.

In fact, the main use of glyceryl trioxide is for heart disease, and it is a drug that every heart patient has. However, in general, the dosage is only one tablet. If the condition worsens or the pain in the precordial area worsens, it must be taken again every 5 minutes.

The main pharmacological action is to relax vascular smooth muscle. Nitroglycerin releases nitric oxide (NO), which, like endothelial relaxing factor, activates guanylate cyclase, increases cyclic guanosine monophosphate (cGMP) in smooth muscle and other tissues, leads to dephosphorylation of myosin light chain, regulates the contractile state of smooth muscle, and causes vasodilation. Nitroglycerin dilates the arteriovenous vascular bed, mainly dilating the veins, and the intensity of its effect is dose-related. Peripheral veins dilate, causing blood to accumulate in the periphery, reducing the amount of blood returning to the heart and lowering the left ventricular end-diastolic pressure (preload). Dilation of the arteries reduces peripheral resistance (afterload).

Arteriovenous dilation reduces myocardial oxygen consumption and relieves angina pectoris. It also has a dilating effect on epicardial coronary artery branches. Therapeutic doses can lower systolic blood pressure, diastolic blood pressure and mean arterial pressure. The effective coronary perfusion pressure can usually be maintained. However, when blood pressure drops excessively or heart rate increases, shortening diastolic filling time, the effective coronary perfusion pressure will decrease. It reduces the increased central venous pressure, pulmonary capillary wedge pressure, pulmonary vascular resistance and systemic vascular resistance. The heart rate is usually slightly increased, probably as a reflective effect of the fall in blood pressure. Cardiac index may increase, decrease, or remain unchanged. Patients with increased left ventricular filling pressures and peripheral resistance and a low cardiac index may have an increased cardiac index. On the contrary, for patients with normal left ventricular filling pressure and cardiac index, intravenous medication can slightly reduce the cardiac index. There are no long-term animal studies to evaluate its carcinogenicity.

Here I would like to remind all my fellow heart disease patients that they must control the dosage when taking nitroglycerin. If you take too much, it will cause very adverse effects on your body. Nitroglycerin is actually a very good medicine with basically no side effects. Moreover, many of them are now made from Chinese patent medicines and have no side effects on our bodies.