Side effects of chloramphenicol

Chloramphenicol is a common antibiotic used to prevent infection of some diseases. It is a broad-spectrum antibiotic. Its main disadvantage is that it has serious adverse reactions on the hematopoietic system, mainly affecting the synthesis of proteins in tissues. Chloramphenicol has very good effects on typhoid fever, some other series of infections, and some bacterial infections. It is important to pay attention to the use of children and elderly patients in daily life.

You must pay attention to it in your daily life and pay attention to check it in your daily life. The main adverse reaction in daily life is the symptom of inhibiting bone marrow hematopoiesis. At the same time, it also has a decreasing effect on the reduction of various blood cells. Therefore, you must consult a doctor's will before taking chloramphenicol in your daily life.

The main adverse reaction is the inhibition of bone marrow hematopoietic function. There are two symptoms: one is a reversible decrease in various blood cells, among which granulocytes decrease first.

One reaction is related to the dose and duration of treatment. Once discovered, the medication should be stopped in time and the disease can be recovered; the second is irreversible aplastic anemia, which, although rare, has a high mortality rate. This reaction is an allergic reaction and has no direct relationship with the dosage or course of treatment. This may be related to the fact that chloramphenicol inhibits the 70S ribosomes in the mitochondria of bone marrow hematopoietic cells, which are the same as those of bacteria. In order to prevent toxic reactions in the hematopoietic system, abuse should be avoided and blood counts should be checked frequently during use. Chloramphenicol can also cause gastrointestinal reactions and superinfection. In addition, a small number of patients may experience allergic reactions such as rash and angioedema, but they are relatively mild. Excessive doses in newborns and premature infants may cause circulatory failure (gray baby syndrome). This is because their livers are underdeveloped and their excretion capacity is poor, which limits the metabolism and detoxification of chloramphenicol and causes the drug to accumulate in the body. Therefore, premature infants and newborns less than two weeks old should avoid using it.

[Notes]

Including chloramphenicol, thiamphenicol and odorless chloramphenicol. Chloramphenicol is a broad-spectrum antibiotic that is rarely used due to its high toxicity to the blood system. Its eye drops are used externally to prevent and treat eye infections. Note: The main adverse reactions include granulocytopenia, thrombocytopenia, aplastic anemia, etc. Long-term use may cause optic neuritis, ataxia and superinfection. Sometimes there are gastrointestinal reactions. It may cause gray baby syndrome in newborns and is therefore contraindicated. It may cause serious reactions in mentally ill patients and is therefore prohibited. Intramuscular injection may cause severe reactions. The antibacterial spectrum of thiamphenicol is similar to that of chloramphenicol, and it does not cause aplastic anemia. However, the dose needs to be reduced in patients with impaired renal function. Children can take odorless chloramphenicol.

The above is the effect of chloramphenicol. We must pay attention to check it in daily life. It is the main adverse reaction caused by chloramphenicol in daily life, which is the symptom of inhibiting bone marrow hematopoiesis. At the same time, it also has a decreasing effect on various blood cell reductions. Therefore, we must consult a doctor's will before taking chloramphenicol in daily life. We must pay attention to the particularity of medication for children and elderly patients in daily life.