Plasma lipoprotein

During the metabolism process of blood lipids, a substance called plasma lipoprotein will be produced. There are many different types of plasma lipoproteins discovered in medicine today. In fact, the so-called plasma lipoprotein is a combination of lipids and proteins in the blood. It is divided into different types such as high-density lipoprotein and low-density lipoprotein according to different densities. If low-density lipoprotein is found during the examination, it means that there is a problem with the body.

The main reason for the appearance of low-density lipoprotein is closely related to people’s diet. If it is a high-fat diet, it can easily lead to the appearance of low-density lipoprotein. In order to help you better understand plasma lipoprotein, this article will introduce you to its related content.

There are several types of plasma lipoproteins. The proportions of proteins and various lipids in different lipoproteins are different, and their densities are also different. They can be divided into four categories by density separation method: chylomicrons (CM, with the lowest density), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL has the highest density). Its main physiological function is to transport exogenous and endogenous fat and cholesterol. When the single or multiple items of plasma lipids such as cholesterol, triglycerides and chylomicrons in serum increase, it can be called hyperlipidemia or hyperlipoproteinemia.

Plasma lipoproteins are classified according to density:

(1) Chylomicrons (<0.95 g/cm3), with very low density, transport triglycerides and cholesterol esters from the small intestine to tissue muscle and adipose tissue.

(2) Very low-density lipoprotein VLDL (0.95-1.006 g/cm3) is produced in the liver and transports lipids to tissues. When VLDL is transported to tissues throughout the body, it is broken down into triglycerides, apoproteins and phospholipids. Finally, VLDL is converted into low-density lipoprotein.

(3) Low-density lipoprotein (LDL, 1.006-1.063 g/cm3) transports cholesterol to tissues. After a series of complex processes, LDL binds to LDL receptors and is ingested by cells.

(4) High-density lipoprotein (HDL, 1.063-1.210 g/cm3), which is also produced in the liver, may be responsible for clearing excess cholesterol from cell membranes. When lecithin cholesterol acyltransferase (LCAT) in plasma transfers fatty acid residues from lecithin to cholesterol to generate cholesterol esters, HDL transports these cholesterol esters to the liver. The liver converts excess cholesterol into bile acids.

Now you have learned about the relevant knowledge about plasma lipoprotein. I would also like to remind you that there is a very important relationship between plasma lipoprotein and arteriosclerosis. If the human body is always in a state of low-density lipoprotein, it will easily lead to the occurrence of arteriosclerosis, which will cause many diseases to your body.