Causes of high rheumatoid factor

Everyone should know something about rheumatoid. This disease is not uncommon nowadays. We should have heard someone say that the rheumatoid factor is high in our daily life. So do you know what a high rheumatoid factor is? If the rheumatoid factor is high, the most obvious consequence is that it will cause rheumatoid arthritis. Let’s take a look at the reasons for high rheumatoid factor. It is also beneficial for disease prevention.

A high rheumatoid factor means that there is a high possibility of suffering from rheumatoid disease. If the rheumatoid factor is high, you must prevent the occurrence of rheumatoid disease in time. Do you know the reason for a high rheumatoid factor? Let's take a look below.

What is the reason for high rheumatoid factor? Experts say that the reasons for high rheumatoid factor include the following:

1. Bacterial factors:

Studies have shown that bacteria may be related to the onset of high rheumatoid factor by stimulating the body to produce antibodies and causing immune pathological damage.

2. Genetic factors:

Rheumatoid arthritis has a higher incidence in certain families, and population surveys have shown that some families have susceptibility genes for this disease, so heredity may play an important role in the onset of the disease.

3. Virus factors:

Related studies have shown that high rheumatoid factor is caused by Epstein-Barr virus infection. Persistently high levels of anti-EB virus-membrane antigen antibodies appear in serum and synovial fluid.

When it comes to rheumatoid factor, many people often associate it with rheumatoid arthritis, thinking that a high rheumatoid factor means rheumatoid arthritis. In fact, this is not true.

Experts say that rheumatoid factor is an autoantibody produced in the body due to infectious factors such as bacteria and viruses, which uses denatured IgG (an antibody) as its antigen. Because this autoantibody was first discovered in patients with rheumatoid arthritis, and has a high titer and lasts longer in the serum of patients with rheumatoid arthritis, it was named rheumatoid factor. In fact, rheumatoid factor can be detected in the serum or lesions of any patient who has denatured IgG and can produce anti-denatured IgG autoantibodies, indicating that rheumatoid factor is not a specific autoantibody for rheumatoid arthritis.

What causes high rheumatoid factor?

In fact, rheumatoid factors are widely present in the human body and have certain physiological effects: ① They can regulate the body's immune response; ② They can activate complement and speed up the elimination of microbial infections; ③ They can clear immune complexes and protect the body from damage by circulating complexes. Rheumatoid factor is only considered positive when the amount of rheumatoid factor exceeds a certain titer.

After reading the above introduction, you should know the reasons for high rheumatoid factor, and have a more detailed understanding of high rheumatoid factor. High rheumatoid factor can lead to rheumatoid arthritis, so we must pay attention to it. If rheumatoid arthritis occurs, we must actively seek treatment to avoid many harms.