What are the drugs that inhibit gastrointestinal motility?

As we all know, when we are sick, in many cases we need to take some medicine to relieve the symptoms and treat the disease. However, although many drugs can cure diseases, they also bring certain side effects to our bodies. Some drugs will inhibit gastrointestinal motility after taking, causing food to not be digested and the body not to feel hungry. So, what are the drugs that inhibit gastrointestinal motility? For these drugs, please see the detailed answers below.

1. Opioid analgesics

Opium is the opium we are familiar with, which is made by drying the juice of poppy fruits. Opioid analgesics are alkaloids extracted from poppies and their derivatives both in vivo and in vitro. They interact with specific central nervous system receptors to relieve pain and produce a sense of well-being. This type of drug mainly includes morphine, codeine, dihydrocodeine, hydromorphone, oxycodone, methadone, fentanyl, pethidine (meperidine) and tramadol.

2. Drugs for the treatment of mental disorders

In recent years, the number of people with mental disorders in my country has continued to rise. With the widespread use of various therapeutic drugs, the constipation problem caused by it has become more and more serious. It can be said that basically all antipsychotic drugs have the potential to cause constipation, and the incidence rate will be higher if two drugs are used in combination. Commonly used drugs include phenothiazines, clozapine, chlorpromazine, loxapine succinate, quetiapine, duloxetine, etc.

3. Anticholine drugs

We are all familiar with atropine. When we have a stomach upset and suffer from severe stomach pain, taking a tablet of atropine (or 654-2) will immediately relieve the pain. We need to know that the pain is caused by spasm of gastrointestinal smooth muscles, and atropine has an antispasmodic effect, which is its analgesic principle.

Cholenaline is a very useful substance for the human body that is ingested from food. When it binds to the cholenaline receptors in our body, it will produce parasympathetic nervous system excitation effects, such as inhibition of cardiac activity, contraction of bronchial gastrointestinal smooth muscles and bladder detrusor muscles, increased secretion of digestive glands, pupil constriction, etc. Anticholine drugs can bind to the choleline receptors first and prevent choleline from binding to the choleline receptors. This will inhibit the excitement of the parasympathetic nerves and cause the opposite effect as mentioned above. In terms of the gastrointestinal tract, smooth muscles will relax, peristalsis will be weak, emptying will be impossible, and defecation will become difficult. Atropine is one such drug.

4. Ganglion blockers

This type of drug can selectively bind to the N1 choline receptors of ganglion cells, competitively blocking the binding of acetylcholine to the receptors, thereby blocking the transmission of nerve impulses in the ganglia, so it is also called ganglion blocking drugs.

This type of drugs mainly includes antihypertensive drugs, representative drugs include hexamethonium bromide, mecamylamine, and cypermethrin. Due to the many and serious adverse reactions, they are no longer used for long-term treatment of hypertension and are only used as anesthetic adjuvants to exert a controlled antihypertensive effect. Adverse reactions include orthostatic hypotension, dry mouth, blurred vision, difficulty urinating, constipation, etc.

5. Calcium antagonists

They are mainly some antihypertensive drugs. While lowering blood pressure, these drugs will also cause the expansion of gastrointestinal smooth muscles, reduce intestinal motility and cause constipation. Such as nifedipine, amlodipine, lacidipine, diltiazem, etc.

What are the drugs that inhibit gastrointestinal motility? The drugs introduced above can all inhibit gastrointestinal motility. Although the drugs have side effects, many times doctors have to prescribe such drugs for the health of patients. When you feel unwell, try to go to a regular hospital in time, so that you can get better treatment results.