Pharmacological effects of Mahonia leaves

The leaves of the Mahonia alba are what we call the leaves of the Phellodendron chinense. They are bitter and cold and have a very good effect of clearing away heat, replenishing deficiency, relieving cough and reducing phlegm. They are especially suitable for treating and solving symptoms of tuberculosis, coughing up blood, dizziness, tinnitus, restlessness and red eyes. At the same time, it is now also used to treat and solve problems such as high blood pressure, because it can effectively inhibit the increase in adrenaline blood pressure and has an inhibitory effect on Escherichia coli and Staphylococcus aureus.

Mahonia leaf, also known as Phellodendron chinense leaf, is mainly distributed in Anhui, Henan, Shaanxi, Zhejiang, Hubei, western Sichuan and other places. The main ingredient is berberine, which tastes bitter and cold. It has the effects of clearing away heat, replenishing deficiency, relieving cough and reducing phlegm. It is suitable for symptoms such as pulmonary tuberculosis, coughing up blood, bone steaming and hot flashes, dizziness, tinnitus, irritability, and red eyes.

Pharmacological Action

1. Antibacterial effect: 25% water decoction of broad-leaved Mahonia has a mild inhibitory effect on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa in vitro.

2. Bioalkalis such as thiocyanate, tetrahydrothiocyanate-N-methylthiocyanate, and palmityl thiocyanate can promote spontaneous movement of isolated intestine at low concentrations (0.001-0.002%), while high concentrations (above 0.01%) can lead to increased tension and inhibition of movement. To the isolated frog heart, rutinine first inhibits and then excites, while terpenoid alkaloids have a mild excitatory effect. In anesthetized rabbits,

3. Blood pressure: Intravenous injection of these bioalkalis can cause a transient or mild drop in blood pressure. There was no significant effect on the blood vessels of the toad's hind limbs. Their antihypertensive effect seems to be unrelated to the central nervous system (it does not lower blood pressure when injected into the vertebral artery, and the pressor reflex caused by blocking carotid blood flow and tracheal occlusion is not affected), and is not affected by atropine, but can inhibit the pressor effect of adrenaline.

4. In an in vivo anti-cancer screening test using Ehrlich ascites carcinoma, it was found that the ingredient tetrandrine contained in it has anti-cancer effects.

5. Others: It has no effect on sciatic nerve, gastrocnemius muscle specimens, body temperature, blood sugar, etc., and does not cause hemolysis. The ten great herbs of South China contain berberine, and its effects can be seen in Coptis chinensis.

toxicity

The median lethal dose of three bioalkaloids extracted from Mahonia tenuifolia (aminobutyric acid thiocyanate, tetrahydroaminobutyric acid-N-methylthiocyanate, and palmitoyl thiocyanate) extracted from Mahonia tenuifolia for intravenous injection in mice was 0.1, 0.08, and 0.098 mg/10g, respectively.

I believe that after reading the above introduction to the roles and pharmacological effects of the Euonymus japonicus leaves, everyone should now have a more comprehensive understanding of its value and medicinal effects. If these plants are used as medicine reasonably, they can achieve good therapeutic effects in preventing and suppressing the symptoms of some diseases, and can also effectively fight cancer.