How to check dry herpes? Two methods are commonly used in clinical practice

Dry herpes is a very common type of herpes in life. Clinically, relevant examination methods are needed to confirm the diagnosis of dry herpes. The following two are the most commonly used.

1. Varicella-zoster virus

(1) Antigen detection can be done by direct immunofluorescence, enzyme immunosorbent staining or ELISA to detect antigens in herpes basal cell scrapings or herpes fluid, which can directly make a diagnosis.

(2) ELISA method for detecting IgM antibodies The incubation period of varicella is generally about 2 weeks. When the rash appears, IgM antibodies have already been produced in the blood. IgM antibodies can last for about 2 months, and detecting IgM antibodies helps to establish a diagnosis. This method has strong specificity and high sensitivity. Herpes zoster is a recurrent infection with low IgM antibody titer and short duration, and 70% can be detected by radioimmunoassay.

2. Herpes simplex virus

(1) Immunofluorescence or enzyme staining to detect antigens is used for cell smears such as cervical exfoliated cells, corneal scraping cells, and ulcer base scraping cells. Antigen detection is performed using direct immunofluorescence or enzyme immunosorbent staining. A positive result indicates infection.

(2) Double antibody sandwich ELISA antigen detection is mainly used to detect HSV antigen in cerebrospinal fluid. It can also be used to detect HSV antigen in patients' herpes fluid, scrapings from the bottom of ulcers, and biopsy tissues.