What causes corpus callosum dysgenesis?

There are many factors that cause corpus callosum dysgenesis, mainly including metabolic factors, chromosomal abnormalities, gene abnormalities or certain special syndromes. For this disease, we must treat it according to the cause.

(1) Toxic-metabolic factors, such as maternal alcoholism or diabetes during pregnancy, or the fetus itself suffering from certain metabolic diseases.

(2) Chromosomal abnormalities, the most common of which are trisomy 8 or trisomy 18.

(3) Genetic abnormalities or certain special syndromes (such as Aicardi syndrome) can be inherited in a dominant, recessive or sex chromosome manner.

(4) The fetus’ brain is infected in early pregnancy.

symptom

The incidence of corpus callosum hypoplasia is very low in normally developing children, but can be as high as two in every 100 children with developmental disabilities. Although corpus callosum hypoplasia is formed in the fetal period, there are no signs after birth that tell us that the baby has this disease; this condition is often discovered during the baby's development through brain ultrasound or brain MRI scans because of neurological symptoms such as delayed motor or language development, epilepsy (especially nodding spasms in infants) or cerebral palsy. If there is anything in the baby's appearance that makes us suspect hypoplasia of the corpus callosum, then the wide separation of the eyes and strabismus should alert us to the possibility of this condition.