What are the gout painkillers?

If you have gout, you must take medication in time to achieve good analgesic and anti-inflammatory effects. There are many analgesics for gout, such as non-steroidal anti-inflammatory drugs, which can inhibit inflammation and achieve analgesic effects. There are also many drugs in this regard, such as loxoprofen sodium, ibuprofen, diclofenac, etc. In addition to medication, daily diet and health care are also important. You should quit smoking and drinking, and avoid eating foods high in purine.

What are the gout painkillers?

In fact, the above-mentioned drugs are collectively referred to as "non-steroidal anti-inflammatory drugs" (NSAIDS) in medicine. The principle of analgesia is to inhibit the activity of human cyclooxygenase (COX), thereby inhibiting the inflammatory response and achieving the analgesic effect. Based on the differences in their mechanisms of action, NSAIDS drugs are further divided into two categories: non-selective and selective. Both types of NSAIDS drugs have their own advantages and disadvantages.

Non-selective NSAIDs have a greater risk of gastrointestinal damage (such as gastrointestinal bleeding) but a lower cardiovascular risk. This type of painkillers includes: loxoprofen sodium, ibuprofen, naproxen, diclofenac, indomethacin, etc.

Selective NSAIDs, on the other hand, have fewer gastrointestinal side effects but relatively more cardiovascular risks. These drugs include: celecoxib, etoricoxib, meloxicam, etc.

How should gout patients choose medicine?

There is no perfect pain medication for people with gout. So which type of painkiller should you choose when gout attacks acutely?

1. Gout patients without underlying diseases

For gout patients who are in good physical condition and do not have concomitant gastrointestinal diseases, cardiovascular diseases, etc., usually both types of drugs can be chosen. The only difference is the speed of onset and the duration of effect. For example, loxoprofen sodium tablets take effect 15 minutes after taking the medicine, and the effect can be maintained for 24 hours after taking the medicine once.

2. Gout patients with gastrointestinal risks

Gastrointestinal risks include a history of gastric bleeding, current gastric and duodenal ulcers, and other risk factors that require a doctor's assessment, such as advanced age, use of anticoagulants, and concomitant use of hormones. If the above conditions exist, selective NSAIDs should be used, and gastric mucosal protectants or proton pump inhibitors (such as rabeprazole) can be added if necessary.

It is important to note that long-term use of both selective and non-selective NSAIDs may cause gastrointestinal bleeding.

3. Gout patients with cardiovascular risk

In theory, it is safer for gout patients with combined cardiovascular risks to choose non-selective NSAIDs, such as loxoprofen sodium tablets and diclofenac, but there is generally no problem with short-term use of selective NSAIDs. If you are taking aspirin, it is best not to take it at the same time as NSAIDs.

4. Pay attention to other side effects of NSAIDS and use them properly

In addition to gastrointestinal and cardiovascular risks, NSAIDS may also pose risks such as liver and kidney damage, and blood system abnormalities. For elderly gout patients and those with existing renal abnormalities, long-term use should be avoided as much as possible, especially not using two NSAIDS drugs at the same time.