What are the symptoms of favism?

The incidence of favism is relatively high in southern my country. It is a hereditary disease caused by incomplete dominant inheritance of the X-linkage. The incidence rate in males is higher than that in females. If there is a history of favism in the family, broad beans must be prohibited to avoid the disease caused by eating broad beans. The symptoms of patients are relatively obvious after the onset of the disease. First, fever will occur, causing chills, leading to jaundice, and severe cases will cause shock and coma, and even acute renal failure.

What are the symptoms of favism? Favism is one of the most common genetic diseases in southern China. It is inherited in an X-linked incomplete dominant manner and is more common in males than in females. Therefore, people with a family history of favism should avoid eating broad beans. So what are the symptoms of favism? Let’s find out together.

The incidence of favism is relatively high in children, and the disease is most common during the broad bean ripening season from March to May each year. The disease usually occurs suddenly 12 to 24 hours after eating broad beans, with symptoms of acute hemolytic crisis: chills, high fever, jaundice, and in severe cases, coma, convulsions, shock, heart failure and acute renal failure. If severe anemia is not treated in time, the patient may die within 1 to 2 days after the onset of the disease. Therefore, when the disease is discovered, you should go to the hospital in time to prevent it from worsening.

The causes of death in children with favism are mostly anemia, severe acidosis, and complications such as acute heart and kidney failure, pneumonia, cerebral parenchymal hemorrhage, etc. Therefore, parents must not take it lightly.

The cause is acute hemolysis caused by contact with fresh broad beans on the basis of hereditary G6PD deficiency. However, the incidence of favism is quite complicated. For example, favism only occurs in people with G6PD deficiency, but not all people with G6PD deficiency will experience hemolysis after eating broad beans.

Patients with favism eat broad beans every year, but they do not necessarily develop the disease every year; the degree of hemolysis and anemia in the patients has no parallel relationship with the amount of broad beans they eat; the incidence rate in adults is significantly lower than that in children. From this, we can infer that in addition to the lack of G6PD in red blood cells, there must be other factors related to the onset of the disease. It can be seen that the mechanism of hemolysis in favism is more complicated than the drug-induced hemolytic anemia caused by G6PD deficiency and needs further exploration.

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