There are many causes of slight tremors in the head, one of which is called essential tremor, which is a movement disorder that often occurs in the head and hands. There are many causes of this disease, and 60% of patients have a family history of it. This is quite harmful to patients, so they must receive good treatment and should also strengthen their conditioning at ordinary times. Disease classification Essential tremor, also known as familial tremor, is found in about 60% of patients. No cross-generational phenomenon has been found in multiple families with essential tremor, and the gender distribution is balanced. It is generally believed that this is an autosomal dominant inheritance, which is fully penetrant before the age of 65 to 70 years. Incomplete penetrance and sporadic cases have also been reported. The clinical features of sporadic and hereditary cases are exactly the same, and it is usually considered to be the same disease, but the related gene abnormalities have not yet been identified. The bimodal characteristics of the age of onset of essential tremor suggest the possibility of two different abnormal genes. The age of onset of familial tremor is earlier than that of sporadic cases, suggesting that early-onset essential tremor is more strongly affected by genetic susceptibility, which can significantly affect the clinical subtype characteristics. Clinical manifestations 1. Family history of essential tremor? Also known as familial tremor, about 60% of patients have a family history, showing autosomal dominant inheritance characteristics. Researchers reported different rates of family history, ranging from 17.4% to 100%. The reason for such a huge difference is that the diagnostic criteria for essential tremor are different. The correct evaluation of the family history of essential tremor depends on inquiry about tremor symptoms and clinical examination. 2. Incidence Typical essential tremor can be found in children, adolescents, and middle-aged and elderly people. The incidence in the general population is 0.3%~1.7%, and increases with age. The incidence rate increases to 5.5% in people over 40 years old, and is 10.2% in people over 65 years old. There is no significant difference in incidence between men and women. It has also been reported that the incidence ratio of women to men in Sweden and Finland is 0.5:0.71. Essential tremor may be more common in left-handed people. 3. Age of onset Essential tremor can occur at any age. There are two views on the peak age of onset. One view is that the distribution of onset age has a bimodal characteristic, that is, in the two age groups of 20-30 years old and 50-60 years old. The other view is that essential tremor rarely occurs in teenagers, and the number of cases increases with age. The average age of onset is 37-47 years old. 4. Course of disease The age of onset of tremor has nothing to do with the progression of the disease. Most scholars believe that the disease always progresses slowly and never remits. Loss of productivity due to tremor begins 10 to 20 years after onset and increases in incidence with disease duration and age. |
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