How should cefazolin sodium skin test solution be prepared?

Cefuroxime is a common drug for many people. It has a strong anti-inflammatory effect and can be used for human body infections or respiratory tract inflammation, rhinitis and other diseases. There are many types of cephalosporins. Cefazolin sodium is also a common drug. A skin test is required before taking or injecting cefazolin sodium to avoid allergic reactions. The preparation of cefazolin sodium skin test liquid is also an important part.

How should cefazolin sodium skin test solution be prepared?

Cefazolin (cephalosporin V) is a first-line antibiotic for perioperative period and is widely used. The standard concentration of skin test solution is 500 μg/ml, and the traditional preparation method is complicated. The improved preparation method of cefazolin skin test solution has satisfactory clinical application effect, which is introduced as follows.

Materials and Methods:

1. Materials: 1 bottle of cefazolin powder (containing 1 g of cefazolin), 1 tube of 0.9% sodium chloride 10 ml, 1 bottle of 0.9% sodium chloride 100 ml, 1 pair of 1 ml5, ml syringes.

2. Methods The preparation of skin test solution follows the principle of aseptic operation. Open the 10 ml ampoule of 0.9% sodium chloride, draw 4 ml with a 5 ml syringe and add it to the bottle of cefazolin powder to completely dissolve it. The concentration is 0.25 g/ml. Draw 0.2 ml of the liquid (containing 50,000 μg of cefazolin) with a 1 ml syringe and add it to the bottle of 100 ml of 0.9% sodium chloride. Draw back the liquid several times and then inject it. After shaking, draw the required amount of skin test solution. The concentration is 500 μg/ml.

Cefazolin sodium dosage

Usual adult dose:

Slow intravenous push, intravenous drip or intramuscular injection, 0.5-1g at a time, 2-4 times a day. For severe infections, the dose can be increased to 6g a day, given intravenously in 2-4 times.

Usual dose for children:

50-100 mg/kg per day, divided into 2-3 times for slow intravenous push, intravenous drip or intramuscular injection.

Patients with impaired renal function can still be given the drug at normal doses when the creatinine clearance rate is greater than 50ml/min. When the creatinine clearance rate is 20-50 ml/min, 0.5 g is taken every 8 hours; when the creatinine clearance rate is 11-34 ml/min, 0.25 g is taken every 12 hours; when the creatinine clearance rate is less than 10 ml/min, 0.25 g is taken every 18-24 hours. The first dose for all patients with varying degrees of renal impairment is 0.5g.

When children with impaired renal function are given cefazolin, first give 12.5 mg/kg, followed by maintenance doses. When the creatinine clearance is above 70 ml/min, normal doses can still be given; when the creatinine clearance is 40-70 ml/min, 12.5-30 mg/kg of body weight should be given every 12 hours; when the creatinine clearance is 20-40 ml/min, 3.1-12.5 mg/kg of body weight should be given every 12 hours; when the creatinine clearance is 5-20 ml/min, 2.5-10 mg/kg of body weight should be given every 24 hours. When this product is used to prevent infection after surgical operations, 1g is generally administered intramuscularly or intravenously 0.5 to 1 hour before the operation. If the operation time exceeds 6 hours, 0.5 to 1g is added during the operation, and 0.5 to 1g is added every 6 to 8 hours after the operation, until 24 hours after the operation.

Intramuscular or intravenous injection, 0.5-1g each time, 3-4 times a day.

Mild infection caused by Gram-positive bacteria: 0.5 g each time, 2 to 3 times a day;

Moderate or severe infection: 0.5-1g per time, 3-4 times per day;

Severe infection: 1-1.5 g each time, 4 times a day;

Urinary tract infection: 1g at a time, twice a day.

The daily dose for children is 20-40 mg/kg, given in 3-4 times; in severe cases, up to 100 mg/kg per day can be used.

For newborns, the dosage should not exceed 20 mg/kg at a time, twice a day.