Symptoms of white matter lesions

When protein becomes pathological, it can lead to the occurrence of a variety of diseases. The typical response of protein to various harmful stimuli is demyelinating changes. It can cause lesions in the nervous system, poisoning, degenerative lesions, and some secondary symptoms such as infarction and deficiency. Patients often suffer from chronic confusion, inattention, emotional disorders, memory loss, etc. It is also an important cause of dementia.

Clinical manifestations of leukoencephalopathy

The most notable clinical manifestation of leukoencephalopathy is an alteration in mental status, which is characterized by deficits in at least one of attention, memory, visual-spatial skills, executive function, and affective state in the absence of aphasia. Mild cases present with a chronic state of confusion, accompanied by inattention, memory loss and emotional dysfunction; more severe cases present with serious sequelae such as dementia, loss of consciousness, stupor and coma. If focal necrosis of the white matter occurs, changes in mental status may be more prominent than general physical signs such as hemiparesis, sensory disturbances, and visual loss.

Causes of white spot disease

White matter disease is a group of demyelinating diseases of the central nervous system whose specific etiology is still unclear. It can be a secondary manifestation of neurological diseases such as infection, poisoning, degeneration, trauma, infarction, etc. The main inferred causes include: 1. Genetic factors: Among white European and American multiple sclerosis patients, many are positive for HLA-A3, -B7 and -DW2 antigens; and patients with metachromatic leukodystrophy have an autosomal recessive genetic disease. 2. Human geographical factors: Multiple sclerosis is more common in cold temperate zones and less common in tropical zones. The incidence rate is high in Europeans, while it is lower in Orientals and Africans; 3. Infectious factors: Measles virus, herpes virus and HIV virus are suspected to be related to multiple sclerosis; JC virus of the Papovaviridae family and SV-40 (Simian Virus) have been proven to be the pathogens of progressive multifocal leukoencephalopathy; the medical community generally recognizes that subacute sclerosing panencephalitis is caused by measles virus.