The drug of choice for treating tuberculosis

As a chronic disease, tuberculosis needs to be treated and controlled with drugs. If the correct treatment is not adopted, it will have life-threatening consequences. So what are the first choice drugs for treating tuberculosis? In response to this issue, we will recommend several drugs that are effective in treating tuberculosis. After diagnosis, tuberculosis patients can choose the drugs that suit them for treatment.

1. Isoniazid has the advantages of strong bactericidal power, oral administration, few side effects and low price. It can inhibit the synthesis of deoxyribonucleic acid (DNA) of tuberculosis bacteria and hinder the synthesis of cell walls. 2. Rifampicin is a semi-synthetic derivative of rifamycin and a broad-spectrum antibiotic. Its mechanism of killing tuberculosis bacteria lies in inhibiting the RNA polymerase of the bacteria, thereby hindering the synthesis of mRNA. 3. Pyrazinamide can kill tuberculosis bacteria in phagocytes and acidic environments. Dosage: 1.5 g per day, taken orally in 3 divided doses. Side effects include hyperuricemia, arthralgia, gastrointestinal reactions and liver damage.

4. Streptomycin is a broad-spectrum aminoglycoside antibiotic that has a bactericidal effect on tuberculosis bacteria, can interfere with the activity of tuberculosis enzymes, and hinder protein synthesis. 5. Ethambutol has an antibacterial effect on tuberculosis bacteria. When used in combination with other anti-tuberculosis drugs, it can delay the emergence of bacterial resistance to other drugs. 6. Sodium aminosalicylate is an antibacterial drug. When used in combination with streptomycin, isoniazid or other anti-tuberculosis drugs, it can delay the development of drug resistance to other drugs. The antibacterial effect may compete with p-aminobenzoic acid (PABA) during the synthesis of folate in Mycobacterium tuberculosis, thereby affecting the metabolism of Mycobacterium tuberculosis. Dosage: Adults 8-12g per day, orally in 2-3 times. Side effects include decreased appetite, nausea, vomiting, diarrhea, etc. If severe, the drug should be discontinued. Taking this medicine after meals can alleviate gastrointestinal reactions. It can also be taken 12g daily by adding 50ml of 5%-10% glucose solution and intravenously dripped in a dark place. After 1 month, it can be taken orally.

7. Thiocarbazide: adverse reactions on the digestive system include poor appetite, nausea, vomiting and constipation, which usually occur 2 months after taking the medicine. If you start the medication with a small dose and gradually increase the dose, the gastrointestinal reaction will be milder. The damage to the liver caused by this drug is manifested as extensive hepatic fatty degeneration, elevated transaminases, and occasional jaundice, which can occur at any time during medication use. If it occurs, the drug should be stopped immediately.

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