What causes blisters on the palate?

The palate is actually a relatively fragile area, and problems often occur here when people don't pay attention, such as dryness, ulcers, and blistering. What causes blisters on the palate? If blisters are found on the palate, people should pay attention to it and understand the cause. After understanding the cause, they can take appropriate measures to treat it.

Herpes simplex virus (HSV) infection of the human body is very common. It is estimated that more than one-third of the world's population has suffered from recurrent herpetic stomatitis, and 30% to 90% of the survey subjects have anti-HSV antibodies in their serum, indicating that they have had or are currently suffering from HSV infection. Oral herpes simplex (herpes simplex of oral cavity) is an acute infectious disease of the oral mucosa and perioral skin, mainly herpes, caused by the herpes simplex virus (HSV). It is called "fever sore" in traditional Chinese medicine and is the most common viral infection in oral clinics.

Treatment 1. Antiviral drugs (1) Acyclovir: Acyclovir (ACV), also known as acyclovir and clovir, is an open-chain guanosine derivative that has a strong inhibitory effect and high selectivity against herpes simplex virus type 1 and type 2. During the disease process, herpes simplex virus induces host cells to synthesize virus-specific thymidine kinase and DNA polymerase. Under the action of thymidine kinase, acyclovir that enters the host cell is phosphorylated into monophosphate, while the enzymes in normal host cells will not phosphorylate acyclovir. Acyclovir monophosphate can be further converted into diphosphate and triphosphate, which accumulate in the active part of the herpes virus-infected cells. It can competitively inhibit the DNA polymerase specific to herpes simplex virus and prevent the replication of the virus without affecting normal host cells. This product is relatively stable in the body after oral administration or intravenous injection, and most of it is excreted through the kidneys in its original form. The quality of renal function can affect the half-life and clearance rate of this product in the body. Therefore, patients with renal damage should reduce the dosage. This drug can also pass through the blood-cerebrospinal fluid barrier and the placental barrier, and can accumulate in breast milk. Because its teratogenic effect is not yet clear, it should be used with caution in children and pregnant and lactating women.

For those with primary infection with herpes simplex virus, acyclovir cannot prevent the virus from lurking in the body, so it cannot control future recurrences. Recent studies suggest that this product is more effective for patients with poor immune system suffering from herpes simplex. The antiviral ability of ACV is HSV-1, HSV-2, varicella-zoster virus and Epstein-Barr virus. Not effective against cytomegalovirus. Its plasma half-life is 2.5 to 3.0 hours. The dosage and administration method are as follows: For primary patients, take 200 mg orally once every 4 hours (5 times/day for adults) for 5 to 7 days. For recurrent oral HSV-1 infection, take 3 to 5 days. Patients with immunodeficiency or complications (such as HSV encephalitis) can use intravenous drip, 5-10 mg/kg, once every 8 hours, for 5-7 days. The side effects of oral ACV are mild, with only gastrointestinal reactions, but there are reports that interferon may increase its neurotoxicity. (2) Ribavirin: Also known as virazole or ribavirin, it is a strong inosine monophosphate (IMP) deoxygenase inhibitor, thereby inhibiting the synthesis of viral nucleic acids and having a broad-spectrum antiviral effect (including DNA and RNA viruses). It has a preventive and therapeutic effect on herpes virus. This product can be taken orally at a dose of 0.6-1 g/d, divided into 3-4 times; intramuscular injection at a dose of 10-15 mg per kilogram of body weight, divided into two times; 0.1% solution can be used as eye drops to treat herpetic conjunctivitis. This product should not be used in large quantities for a long time to avoid causing serious gastrointestinal reactions. It is prohibited for pregnant women. (3) Interferon and polyinosin: Interferon is a glycoprotein synthesized by the body's cells in response to viral infection or some non-viral inducers. It has high biological activity and can promote the killing effect of the body's natural killer cells (NK cells) and macrophages on virus-infected cells, and can inhibit the replication and proliferation of viruses in newly invaded tissue cells. Exogenous interferon and endogenous interferon released from infected cells act on receptors on the cell membrane of uninfected cells, inducing the production of a variety of cytoplasmic enzymes, destroying viral RNA, affecting the synthesis of viral proteins, and limiting the spread of viral infection.

<<: How to quickly cure palate ulcer

>>: Maxillary protrusion surgery