Clinical significance of prolonged thrombin time

Prothrombin time refers to the conversion of prothrombin into thrombin, causing plasma coagulation, when the body lacks platelet plasma or there is an excess of tissue factor. Prolonged thrombin time is of great clinical significance. Through laboratory tests, it can be used to diagnose some hemorrhagic diseases, such as severe hepatitis or cirrhosis.

Clinical significance of prolonged thrombin time

The prothrombin time test is not only suitable for the diagnosis of congenital coagulation diseases and acquired hemorrhagic diseases of the extrinsic coagulation pathway, but is also of great significance for the diagnosis of severe hepatitis and early cirrhosis. It is also the preferred test indicator for monitoring oral anticoagulant drug treatment in clinical practice. 1. Prolonged: congenital deficiency of coagulation factors II, V, VII, and X; fibrinogen (Fg) deficiency (<0.5g/L); afibrinogen (Fg)emia; dysfibrinogen (Fg)emia; disseminated intravascular coagulation; primary hyperfibrinolysis; severe acute and chronic liver disease; obstructive jaundice; Vit-K deficiency; increased circulating anticoagulants, etc. 2. Shorten: congenital factor V excess, thrombotic diseases, disseminated intravascular coagulation (DIC) hypercoagulation period; oral contraceptives, etc.

Precautions

1. Collect blood from the upper limb vein on an empty stomach. 2. The blood collection process strictly follows aseptic operation, the same type of test tubes are used, and sodium citrate is used for anticoagulation. 3. Prothrombin time was tested under different conditions using the same experimental test reagents. 4. Strictly follow the operating procedures during the testing process to avoid other factors affecting the test results.

Thrombin is the time it takes for blood to clot after the addition of standardized prothrombin to plasma. The normal range is 16 to 18 seconds; if it exceeds the normal control by more than 3 seconds, it is abnormal. Prolonged thrombin time is seen in decreased plasma fibrinogen or structural abnormalities; clinical use of heparin, as well as increased heparin-like anticoagulants and hyperfibrinolytic function in liver disease, kidney disease and systemic lupus erythematosus. You can consult your doctor to check for related diseases.